Category Archives: Health

Three identical strangers, and the genetics of personality

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Inheritability of traits is one of the greatest of insights; it’s so significant and apparent, that one who does not accept it may safely be called a dullard. Personal variation exists, but most everyone accepts that if your parents are tall, you are likely to be tall; If they are dark, you too will likely be dark, etc., but when it comes to intelligence, or proclivities, or psychological leanings, it is more than a little impolite to acknowledge that genetics holds sway. This unwillingness is glaringly apparent in the voice-over narration of a popular movie about three identical triplets who were raised separately without knowing of one another. The movie is “Three identical strangers”, and it recounts their meeting, and their life afterwards.

Triplets, raised separately, came out near identical.

As one might expect, given my introduction, though raised separately, the three showed near identical intelligence, and near identical proclivities: two of them picked the same out-of-the way college. All of them liked the same sort of clothes and had the same taste in women. There were differences as well: one was a more outgoing, one was depressed, but in many ways, they were identical. Meanwhile, the voice-over kept saying things like, “isn’t it a shame that we never saw any results on nature/nurture from this study.” Let me clear this us: genetics applies to psychology too. It’s not all genetics, but it is at least as influential as upbringing/ nurture.

This movie also included pairs of identical twins, raised separately, they also showed strong personality similarities. It’s a finding that is well replicated in broader studies involving siblings raised separately, and unrelated adoptees raised together. Blood, it seems, is stronger than nurture. See for example the research survey paper, “Genetic Influence on Human Psychological Traits” Journal of the American Psychological Society 13-4, pp 148-151 (2004). A table from that paper appears below. Genetics plays a fairly strong role in all personal traits including intelligence, personality, self-control, mental illness, criminality, political views (even mobile phone use). The role is age-dependent, though so that intelligence (test determined) is strongly environment-dependent in 5 year olds, almost entirely genetic in 25-50 year olds. One area that is not strongly genetic, it seems, is religion.

In a sense, the only thing surprising about this result is that anyone is surprised. Genetics is accepted as crucial for all things physical, so why not mental and social. As an example of the genetic influence on sports, consider Jewish chess genius, Lazlo Polgar: he decided to prove that anyone could be great at chess, and decided to train his three daughters: he got two grand masters and an international master. By comparison, there are only 2 chess grand masters in all of Finland. Then consider that there are five all-star, baseball players named Alou, all from the same household, including the three brothers below. The household has seven pro baseball players in all.

Most people are uncomfortable with such evidence of genetic proclivity. The movie has been called “deeply disturbing” as any evidence of proclivity contradicts the promise of education: that all men are equal, blank slates at birth that can be fashioned into whatever you want through education. What we claim we want is leaders — lots of them, and we expect that education will produce equal ratios of woman and men, black and white and Hispanic, etc. and we expect to be able to get there without testing for skills, — especially without blind testing. I notice that the great universities have moved to have testing optional, instead relying on interviews and related measures of leadership. I think this is nonsense, but then I don’t run Harvard. As a professor, I’ve found that some kids have an aptitude and a burning interest, and others do not. You can tell a lot by testing, but the folks who run the universities disagree.

The All star Alou brothers share an outfield.

University heads claim that blind testing is racist. They find that some races score poorly on spacial sense, for example, or vocabulary suggesting that the tests are to blame. There is some truth to these concerns, but I find that the lack of blind testing is more racist. Once the test is eliminated, academia finds a way to elevate their friends, and the progeny of the powerful.

The variety of proclivities plays into an observation that you can be super intelligent in one area, and super stupid in others. That was the humor of some TV shows: “Big Bang Theory” and “Fraser”. That was also the tragedy of Bobby Fischer. He was brilliant in chess (and the child of brilliant parents), but was a blithering idiot in all other areas of life. Finland should not feel bad about their lack of great chess players. The country has produced two phone companies, two strong operating systems, and the all time top sniper.

Robert Buxbaum, May 15, 2022

Induction

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Most of science is induction. Scientists measure correlation, for example that fat people don’t run as much as thin people. They then use logic to differentiate cause from effect that is do they not run because they are fat, or are they fat because they don’t run, or is everything base on some third factor, like genetics. At every step this is all inductive logic, but that’s how science is done.

The lack of certainty shows up especially commonly in health work. Many of our cancer cures are found to not work when studied under slightly different conditions. Similarly with weight los, or heart health. I’d mentioned previously that CPAPs reduce heart fibrillation, and heart filtration is correlated with shortened life, but then we find that CPAP use does not lengthen life, but seems to shorten it. (see a reason here). That’s the problem with induction; correlation isn’t typically predictive in a useful way.

Despite these problems, this is how science works. You look for patterns, use induction, find an explanation, and try to check your results. I have an essay on the scientific methods, with quotes from Sherlock Holmes. His mysteries are a wonderful guide, and his inductive leaps are almost always true. Meanwhile, the inductive leaps of Watson and Lastrade are almost always false.

Robert Buxbaum, May 9, 2022

Hypochondriacs anonymous: the first step is admitting you don’t have a disease.

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I’m writing a book about reverse psychology; please don’t buy it.

This one’s not by Rappaport

The judge said I had to keep 6 feet away from my ex-wife. So I buried her under the patio.

Robert Buxbaum: the above 3 jokes are from Jack Rappaport — He sometimes sells jokes. April 13, 2022. The ones below are from Gahan Wilson, and the one at right, I don’t know.

These last two are from Gahan Wilson

C-PAPs do not help A-Fib, and seem to make heart health worse.

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In this blog-post, I’d like to report on the first random study of patients with Atrial fabulation, A-Fib, and sleep apnea, comparing the health outcome of those who use a C-PAP, a “Continuous Positive Airway Pressure” device, to the outcome those who do not. The original study was published in May, 2021 (read it here) in the American Journal of Respiratory and Critical Care Medicine. The American Journal, Pulmonary Advisor published a more-popular version here.

As a background, if you are over 65 and overweight, there is a 25% chance or so that your heart rate will begin to surge semi-randomly, and that it will flutter. This is Atrial fabulation, A-Fib. It tends to get worse and tends to lead to heart attacks and strokes. People with A-fib tend to be treated with drugs, aspirin, warfarin, beta blockers, and anti arrhythmics. They also tend to be prescribed a C-PAP because overweight, older folks tend to snore and wake up a lot during the night (several times per hour: apnea).

A C-PAP definitely stops the snoring and the Apnea, and the assumption was that it would help your heart as well, if only by giving you a better night’s sleep. As it turns out, the C-PAP seems to decrease heart health — significantly.

For this study, adult patients between 18 and 75 years old diagnosed with paroxysmal A-Fib (that’s occasional AF) were screened for moderate to severe sleep apnea. Those who agreed to participate were randomly assigned to either a treatment of C-PAP plus usual care (drugs mostly) or just usual care for the next 5 months. Of the 109 who enrolled in the study, 55 got the C-PAP plus usual care, 54 got usual care alone. The outcome was that there were 9 serious, adverse heart events (strokes and heart attacks); 7 were in the C-PAP group.

The CPAP pressure was, on average, 6.8 cm H2O; mean time of use was 4.4±1.9 hours per night. The C-PAPs did their jobs on the apnea too, reducing residual apnea-hypopnea to 2.3±1.9 events per hour for those in the C-PAP group.

There was a non-statistically significant reduction is AF among the C-PAP group. They reduced their time in AF by 0.6 percentage points compared to the control group  (95% CI, -2.55 to 1.30; P =.52). That not a statistically significant difference, and is most likely random.

There was a statistically significant decrease in heart health, though. A total of 7 serious adverse events occurred in the C-PAP group and only 2 in the control group. A total of 9 is a relatively small number of events, but there is a strong statistical difference between 7 and 2.

The authors conclude: “CPAP treatment does not seem to reduce or prevent paroxysmal AF.” They should also have concluded that it reduced heart health with a statistical confidence of ~82%: (1-2(36+10)/512) =82%. See more on this type of statistics.

A possible explanation of why a C-PAP would would make heart health worse is an outcome of the this recent sleep study (link here). It appears that the C-PAP helps restore breathing, but by doing so, it interferes with a mechanism the body uses to deal with A-fib. It seems that, for people with A-Fib, their bodies use breathing stoppages to get their heart back into rhythm. For these people, many of their breathing stoppage are not obstructive, but a bio-pathway to raise the CO2 level in the blood and thus regulate heart rate. The use of a C-PAP prevents this restorative mechanism and this seem to be the reason it is destructive to the heart-health of patients with A-fib. On the other hand, a C-PAP does improve the sleep those patients whose apnea is obstructive. It seems to me that sleep studies should do a better job distinguishing the two causes of apnea. C-PAPs seem counter-indicated for patients with A-fib.

Robert Buxbaum, March 30, 2022. I was diagnosed with apnea and A-Fib some years ago. The sleep doctor prescribed a C-PAP and was adamant that I had to use it to keep my heart healthy. There were no random studies backing him up or contradicting him until now.

Vaccines have not decreased the US COVID death rate

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I’m not sure why this is, but a quick look at the death statistics shows that it is no lower today than it was a year ago. Vaccines seem to help the individual, but they don’t seem to do much for society as a whole.

Johns Hopkins data. COVID 19 death rate in the USA.

That the death rates are the same as last November is bad, especially since one major effect of COVID has been to wipe out nearly all our old folks, decreasing the lifespan of US men by 2-3 years. With a 70% vaccination rate (adults, 60% overall), and few old people, you ‘d expect our death rate this year would be lower than last.

Currently, at least, the trend-line looks positive, but that’s likely a mirage. It is common to add more deaths to the tally, retroactively a few weeks out as many deaths take weeks to report and more weeks to be counted as COVID. For what it’s worth, I’m vaccinated, two shots and a booster. I also take aspirin, and have gotten a pneumonia shot. I think it helps. What do I know?

Robert Buxbaum, November 18, 2021

Deadly incurable viruses abound: The plagues to come.

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As we discuss the effectiveness of the various COIVD vaccines, and ask if we will need another booster in a year, this time for the delta variant, or epsilon, it’s worth noticing that none of these is that deadly, especially if you’ve had a previous version. There are far worse viruses out there, like Ebola-Zaire, for example. This virus kills 60-90% of the people infected, typically by causing the body’s connective tissue to dissolve. Now that’s a deadly virus; imagine an ebola pandemic.

We live surrounded by many really deadly viruses, most of them incurable. In general our protection from them is that they usually show a slow infection rate or a slow progress to death. Drug resistant leprosy is one of these. Here’s the beginnings of a list of deadly viruses we could worry about: Lassa, Rift Vally, Oropouche, Rocio Q Guanarito, VEE, Marburg, Herpes B, Monkey Pox, Dengue, Chikunguanya, Hantavirus, Machupo, Junin, Rabies-like Mokola, drug-resistant leprosy, Duvenhage, LeDantec, Kyasanur, Forest Brain virus, HIV-AIDs, Simliki, Crimean-Congo virus, Sindbis, O’nyongnyong, Sao Paulo, SARS, Ebola Sudan, Ebola Zaire, Ebola Reston, Mid-East Respiratory (MERS), Zika, Delta-COVID. (I got 2/3 of this list from a 1993 book called “The Hot Zone” about the first US outbreak of Ebola — Washington DC in 1989 — a good book, worth a read).

Ebola is a string-like virus with loops. It causes your body to dissolve and bleed out from every pore. The strings form crystals that are virtually immortal.

As an ilk, these viruses are far older than we are, older than the first cellular creatures, and far tougher. They are neither dead nor alive, and can last for years generally without air, water or food if the temperature is right. Though they do not move on their own, nor eat in any normal sense, they do reproduce, and they do so with a vengeance. They also manage to evolve by an ingenious sexual mechanism. In a sense, they are the immune system of the earth, protecting the earth from man or any other invasive life form. We humans have only survived the virus for 100,000 years or so. Long term, the viruses are likely to win.

Zika is a ball-shaped virus. Incurable, it causes encephala. Ball-viruses are not as immortal as string viruses. COVID is a ball virus with spikes, a crown virus.

Some viruses are string shaped; Marburg and Ebola are examples. Such viruses can crystalize and live virtually forever on dry surfaces. Other viruses are ball-shaped, COVID and Zika, for example. These are more easily attacked on surfaces, e.g. by iodine. They become inactive after just a few minutes in air– and are killed instantly by iodine, alcohol, bleach, or peroxide.

Most viruses enter by cuts and body fluids. This is the case with AIDS and herpes. Others, like measles, shingles, and Zika, enter by way of surfaces and the hands. Virus-laden droplets collect on surfaces and are brought to a new host when the surface is touched and hand-transported to the nose or eyes. A few viruses, like SARS, Ebola, and COVID-19 can enter the body by breathing too. I’ve collected some evidence in favor of Iodine as a surface wipe, a hand wipe and as mouthwash in this previous essay.

Dr. Robert E. Buxbaum, November 3, 2021. The US has three facilities where they deal with the most deadly, contagious viruses. One is in Washington DC; they had leak in 1989, a part of the ebola outbreak. China has only one such facility, in Wuhan, China. It’s one block from where the COVID-19 outbreak supposedly originated. Have a nice day.

People would rather get electric shocks than think for 15 minutes.

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A review of some studies on the difficulty of sitting in one’s own thoughts.

There is a joke: what is the opposite of speaking?

It’s waiting to speak.

Most people find it uncomfortable to sit still and be quiet. Even listening is a pain. People sit brewing in their thoughts of what they are going to say. Silence is uncomfortable enough that solitary confinement for a few days is torture.

But what about a few minutes. Almost everyone can sit still and listen for 15 minutes as their friend drones on, especially if they are paid for it. Still, it’s uncomfortable, and a study set out to understand how uncomfortable. It turns out that a majority of men, 67% would rather give themselves electric shocks than sit and think or listen. Women, too find it unpleasant; some 25% of women preferred to give themselves electric shocks rather than sit and think. You’ll find a brief review of this and similar work copied above, or you can read the full study: Wilson et al 2014, “The challenge of the disengaged mind“.

The effect of the COVID-19 lockdowns was to remove virtually every bit of agreeableness, extroversion, conscientiousness, and openness, while fueling neuroticism. Data for 2020.

The effect of the COVID-19 lockdowns has been massive. Those involved in government discussions don’t seem to realize how massive, perhaps because they’re in constant contact with people, speaking and being spoken too. Most of us were not so lucky. We experienced partial isolation. A recent study suggests that almost every measure of happiness disappeared during the summer months of 2020: US agreeableness, extroversion, conscientiousness, and openness all declined dramatically, see data above. Decisiveness too; a lingering effect is an inability to make decisions. My hope is that government officials can resist the temptation for more lockdowns and mandates; mental health is health too.

If lockdowns do come, or if you are depressed for any other reason, you might consider exercise, or lithium, or counseling. At least decide to wake up at a fixed time every morning. Under COVID watch conditions, depression is the new normal. Here’s a joke on marriage counseling.

Robert Buxbaum, October 27, 2021

COVID is 1/50 as deadly in China, Hong Kong, Taiwan, Korea…

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I may be paranoid, but that doesn’t mean I’m crazy. COVID-19 shows a remarkably low death rate in Asia, particularly Eastern Asia, compared to the US or Europe or South America. As of this month, there have been 734,600 US deaths from COVID-19, representing 0.22% of all Americans. Another way of stating this is 2.2 deaths per thousand population. In one year, COVID has lowered the life expectancy of US men by 2.1 years; with the decline worst among hispanic men. The COVID death rate is very similar in Europe, and higher in South America (in Peru 0.62%), but hardly any deaths in East Asia. In China only 4,636 people, 0.003% of the population. That’s 1/700th the rate in the US, and almost all of these deaths are in western China. They no longer bother with social distancing.

The low death rate in East Asia. was noted by the BBC over a year ago. Based on today’s data from Worldometer, here, the low death rates continue throughout East Asia, as graphed at right. In Hong-Kong the death rate is 0.03 per thousand, or 1/70th the US rate. In Taiwan, 0.04 per thousand; in Singapore, 0.01 per thousand; in S. Korea 0.04 per thousand; Cambodia and Japan, 0.1 per thousand. The highest of these countries shows 1/20 the death rate of the US. This disease kills far fewer East Asians than Westerners. This difference shows up, for example in a drop in the lifespan of male Americans by 2.16 years. The lifespan of male Hispanics dropped more, by 4.58 years. In China, Japan, and Korea the lifespans have continued to increase.

Life expectancy for US males has dropped by 2.16 years. It’s dropped more for Hispanic and Black Americans. Data for women is similar but not as dramatic.

My suspicion is that this was a racially targeted bio-weapon. But perhaps the targeting of westerners reflects a cultural lifestyle difference. Mask use has been suggested, but I don’t think so. In many high mask countries the death rate is high, while in low mask Taiwan and Korea it’s low, only 0.04 COVID deaths per thousand. Even Sweden, with no masks reports only 1.4 per thousand deaths; that’s 2/3 the death rate of the US. Masks do not seem to explain the difference.

Another lifestyle difference is obesity; Americans are fat. Then again, Peru was hit far worse than we were, and Peruvians are thin. Meanwhile, in Hong Kong, folks are fat, but the death rate is small. Another cultural difference is medicine, but I don’t believe Sweden, Germany, and France have worse healthcare than Taiwan or Cambodia. Cambodia saw 1/20 the US COVID death rate.

My suspicion is that this disease targets by race because it was designed that way. If it isn’t a bio weapon, it certainly behaves like one. I may be paranoid here, but that’s the way it seems.

As a side issue, perhaps related, I note that China keeps pushing for the to close its manufacturing in the interest of CO2 abatement, while they keep building coal burning power plants to fill the manufacturing need that we abandon. I also notice that they hit us with tariffs while protesting our tariffs, that they steal our intellectual property, and that they are building islands in the sea between China and Japan. There is war-tension between our countries, and Western-targetting virus appears right outside of China’s top-security virus lab — their only level 4 lab — I’m guessing it’s not a total coincidence.

Robert Buxbaum, October 12, 2021

Exercise helps fight depression, lithium helps too.

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With the sun setting earlier, and the threat of new COVID lockdowns, there is a real threat of a depression, seasonal and isolation. A partial remedy is exercise; it helps fight depression whether you take other measures not. An article published last month in the Journal of Affective Disorders reviewed 22 studies of the efficacy of exercise, particularly as an add-on to drugs and therapy. Almost every study showed that exercise helped, and in some studies it helped a lot. See table below. All of the authors are from the University of British Columbia. You can read the article here.

From “Efficacy of exercise combined with standard treatment for depression compared to standard treatment alone: A systematic review and meta-analysis of randomized controlled trials.” by JacquelineLee1 et al.In virtually every study, exercise helps fight depression.

For those who are willing to exercise, there are benefits aside from mental health. Even a daily walk around the block helps with bone strength, weight control, heart disease, plus the above mentioned improvement in mood. More exercise does more. If you bicycle without a helmet, you’re likely to live longer than if you drive.

For those who can’t stand exercise, or if exercise isn’t quite enough to send away the blues, you can try therapy, medication, and/or diet. There is some evidence that food that are high in lithium help fight depression. These food include nuts, beans, tomatoes, some mineral waters, e.g. from Lithia springs, GA. The does is about 1/100 the dose given as a bipolar treatment, but there is evidence that even such small doses help. Lithium was one of the seven ingredients in seven up — it was the one that was supposed to cheer you up. See some research here.

Robert Buxbaum, October 7, 2021.

Of cigars and marriage, Kipling and Freud.

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My last post included a rather gruesome bit of poetry by Rudyard Kipling where he describes the Afghani women coming to kill the wounded British soldiers in the first Afghan war. It’s sexist, or anti-sexist, if you like. Since it reverses a stereotype of the non-violent, female home-body. Then again the Afghanis had wiped out an entire British army, killing virtually everyone including civilians.

What follows is The Betrothed, one of Kipling’s first published poems, appearing in “the civil and military gazette”, Lahor, India (near Afghanistan), November, 1888. Kipling was an assistant editor). It has a more traditional view of women, or of British women who do not go out murdering, but who do wish to control/ stop a British man’s cigar smoking. In a sense, such stoppage is murder. The inspiration was a breach of ‘Promise of Marriage’ case in Glasgow, August 1888, where a young woman, Maggie Watson, sued her fiancee because he continued to smoke cigars after she insisted he stop. Kipling explores the psychology of the choice between smoking and marriage. I think Freud would approve.

The Betrothed.

OPEN the old cigar-box, get me a Cuba stout, For things are running crossways, and Maggie and I are out. 

We quarrelled about Havanas—we fought o’er a good cheroot, And I knew she is exacting, and she says I am a brute. 

Open the old cigar-box—let me consider a space; In the soft blue veil of the vapour musing on Maggie’s face. 

Maggie is pretty to look at—Maggie’s a loving lass, But the prettiest cheeks must wrinkle, the truest of loves must pass. 

There’s peace in a Larranaga, there’s calm in a Henry Clay; But the best cigar in an hour is finished and thrown away— 

Thrown away for another as perfect and ripe and brown— But I could not throw away Maggie for fear o’ the talk o’ the town! 

Maggie, my wife at fifty—grey and dour and old— With never another Maggie to purchase for love or gold! 

And the light of Days that have Been the dark of the Days that Are,
And Love’s torch stinking and stale, like the butt of a dead cigar— 

The butt of a dead cigar you are bound to keep in your pocket— With never a new one to light tho’ it’s charred and black to the socket! 

Open the old cigar-box—let me consider a while. Here is a mild Manila—there is a wifely smile. 

Which is the better portion—bondage bought with a ring, Or a harem of dusky beauties, fifty tied in a string? 

Counsellors cunning and silent—comforters true and tried, And never a one of the fifty to sneer at a rival bride? 

Thought in the early morning, solace in time of woes, Peace in the hush of the twilight, balm ere my eyelids close, 

This will the fifty give me, asking nought in return, With only a Suttee’s passion—to do their duty and burn. 

This will the fifty give me. When they are spent and dead, Five times other fifties shall be my servants instead. 

The furrows of far-off Java, the isles of the Spanish Main, When they hear my harem is empty will send me my brides again. 

I will take no heed to their raiment, nor food for their mouths withal, So long as the gulls are nesting, so long as the showers fall. 

I will scent ’em with best vanilla, with tea will I temper their hides, And the Moor and the Mormon shall envy who read of the tale of my brides. 

For Maggie has written a letter to give me my choice between. The wee little whimpering Love and the great god Nick o’ Teen. 

And I have been servant of Love for barely a twelvemonth clear, But I have been Priest of Cabanas a matter of seven year; 

And the gloom of my bachelor days is flecked with the cheery light Of stumps that I burned to Friendship and Pleasure and Work and Fight. 

And I turn my eyes to the future that Maggie and I must prove, But the only light on the marshes is the Will-o’-the-Wisp of Love. 

Will it see me safe through my journey or leave me bogged in the mire? Since a puff of tobacco can cloud it, shall I follow the fitful fire? 

Open the old cigar-box—let me consider anew— Old friends, and who is Maggie that I should abandon you? 

A million surplus Maggies are willing to bear the yoke; And a woman is only a woman, but a good Cigar is a Smoke. 

Light me another Cuba—I hold to my first-sworn vows. If Maggie will have no rival, I’ll have no Maggie for Spouse! 

Sigmund Freud with his cigar. The whole attraction of cigars, is a strange one, as Freud knew better than most. Cigars are deadly, but casual, often with a good flavor, and a sucking comfort. The death-risk of one is small and distant. Cigars thus represent risky fun they are thus life, in a temporary, risky way. Marriage is permanence and safe, and binding. The binding permanence is a sort of death, but children are good, and that’s life. Freud’s choice was to smoke himself to death. Kipling got married and eventually gave up smoking.

Robert E. Buxbaum, September 17, 2021. Kipling has a great sense of words, and an attractive sense of the subjects, great and small. For years he was the voice of his generation in Britain, but by the end of his life, his views were unacceptable. sexist. On the other hand, he remained staunchly anti-Nazi, anti eugenics, and anti Soviet. By comparison, George Bernard Shaw was a vocal fan of Stalin, of Hitler, and of the eugenic removal of Jews and other undesirables. Shaw’s words remain fashionable, while Kipling’s do not. Such is the nature of fame.