Category Archives: Michigan State University

Pneumonia vaccine in the age of COVID

3 Replies

A few days ago, I asked for and received the PCV-13 pneumonia vaccine, and a few days earlier, the flu shot. These vaccines are free if you are over 65, but you have to ask for them. PCV-13 is the milder of the pneumonia vaccines, providing moderate resistance to 12 common pneumonia strains, plus a strain of diphtheria. There is a stronger shot, with more side-effects. The main reason I got these vaccines was to cut my risk from COVID-19.

Some 230,00 people have died from COVID-19. Almost all none of them were under 20, and hardly any died from the virus itself. As with the common flu, they died from side infections and pneumonia. Though the vaccine I took is not 100% effective against event these 13 pneumonias, it is fairly effective, especially in the absence of co-morbidities, and has few side effects beyond stiffness in my arm. I felt it was a worthwhile protection, and further reading suggests it was more worthwhile than I’d thought at first.

It is far from clear there will be a working vaccine for SARS-CoV-2, the virus that causes COV-19. We’ve been trying for 40 years to make a vaccine against AIDS, without success. We have also failed to create a working vaccine for SARS, MERS, or the common cold. Why should SARS-CoV-2 be different? We do have a flu vaccine, and I took it, but it isn’t very effective, viruses mutate. Despite claims that we would have a vaccine for COVID-19 by early next year, I came to imagine it would not be a particularly good vaccine, and it might have side effects. On the other hand, there is a fair amount of evidence that the pneumonia vaccine works and does a lot more good than one might expected against COVID-19.

A colleague of mine from Michigan State, Robert Root Bernstein, analyzed the effectiveness of several vaccines in the fight against COVID-19 by comparing the impact of COVID-19 on two dozen countries as a function of all the major inoculations. He found a strong correlation only with pneumonia vaccine: “Nations such as Spain, Italy, Belgium, Brazil, Peru and Chile that have the highest COVID-19 rates per million have the poorest pneumococcal vaccination rates among both infants and adults. Nations with the lowest rates of COVID-19 – Japan, Korea, Denmark, Australia and New Zealand – have the highest rates of pneumococcal vaccination among both infants and adults.” Root-Bernstein also looked at the effectiveness of adult inoculation and child inoculation. Both were effective, at about the same rate. This suggests that the the plots below are not statistical flukes. Here is a link to the scientific article, and here is a link to the more popular version.

An analysis of countries in terms of COVID rates and deaths versus pneumonia vaccination rates in children and adults. The US has a high child vaccination rate, but a low adult vaccination rate. Japan, Korea, etc. are much better. Italy, Belgium, Spain, Brazil, and Peru are worse. Similar correlations were found with child and adult inoculation, suggesting that these correlations are not flukes of statistics.

I decided to check up on Root-Bernstein’s finding by checking the state-by state differences in pneumonia vaccination rates — information available here — and found that the two US states that were hardest hit by COVID, NY and NJ, have among the lowest rates of inoculation. Of course there are other reasons at play. These states are uncommonly densely populated, and the governments of both made the unfortunate choice of sending infected patients to live in old age homes. At least half of the deaths were in these homes.

Pneumonia vaccination may also explain why the virus barely affected those under 20. Pneumonia vaccines was available only in 2000 or so. Many states then began to vaccinate about then and required it to attend school. The time of immunization could explain why those younger than 20 in the US do so well compared to older individuals, and compared to some other countries where inoculation was later. I note that China has near universal inoculation for pneumonia, and was very mildly hit.

I also took the flu shot, and had taken the MMR (measles) vaccine last year. The side effects, though bad, are less bad than the benefits, I thought, but there was another reason, and that’s mimicry. It is not uncommon that exposure to one virus or vaccine will excite the immune system to similar viruses, so-called B cells and T-cell immunity. A recent study from the Mayo Clinic, read it here, shows that other inoculations help you fight COVID-19. By simple logic, I had expected that the flu vaccine would help me this way. The following study (from Root-Bernstein again) shows little COVID benefit from flu vaccine, but evidence that MMR helps (R-squared of 0.118). Let men suggest it’s worth a shot, as it were. Similar to this, I saw just today, published September 24, 2020 in the journal, Vaccines, that the disease most molecularly similar to SARS-CoV-2 is pneumonia. If so, mimicry provides yet another reason for pneumonia vaccination, and yet another explanation for the high correlations shown above.

As a final comparison, I note that Sweden has a very high pneumonia inoculation rate, but seems to have a low mask use rate. Despite this, Sweden has done somewhat better than the US against COVID-19. Chile has a low inoculation rates, and though they strongly enforced masks and social distance, it was harder hit than we were. The correlation isn’t 100%, and masks clearly do some good, but it seems inoculation may be more effective than masks.

Robert Buxbaum, November 7, 2020.

Beavers, some of the best dam builders

5 Replies

I ran for water commissioner in 2016 (Oakland county, Michigan; I’ll be running again in 2020), and one of my big issues was improving our rivers. Many are dirty and “flashy”. Shortly after a rain they rise too high and move dangerously fast. At other times, they become, low, smelly, and almost disappear. There are flash floods in these rivers, few fish or frogs, and a major problem with erosion. A big part of a solution, I thought, would be to add few small dams, and to refurbish a few others by adding over-flow or underflow weirs. We had a small dam in the middle of campus at Michigan State University where I’d taught, and I’d seen that it did wonders for river control, fishing, and erosion. The fellow I was running against had been removing small dams in the belief that this made the rivers “more natural”. The Sierra Club thought he was right doing this; the fishing community and some homeowners and MSU alumni thought I was. My problem was that I was a Republican running in a Democratic district. Besides, the county executive, L. Brooks Patterson (also a Republican) was a tightwad. Among my the first stops on my campaign trail was to his office, and while he liked many of my ideas, and promised to support me, he didn’t like the idea of spending money on dams. I suggested, somewhat facetiously, using beavers, and idea that’s grown on me since. I’m still not totally convinced it’s a good idea, but bear with me as I walk you through it.

Red Cedar River dam as seen from behind the Michigan State University Administration Building.

Small dam on the Red Cedar River at Michigan State University behind the Administration Building. The dam provided good fishing and canoeing, and cleaned the water somewhat.

The picture at right shows the dam on the Red Cedar River right behind the Administration building at Michigan State University, looking south. During normal times the dam slows the river flow and raises the water level high enough to proved a good canoe trail, 2 1/2 miles to Okemos. Kids would fish behind the dam, and found it a very good fishing spot. The slow flow meant less erosion, and some pollution control. The speed of flow and the height of the river are related; see calculation here. After a big rain, a standing wave (a “jump”) would set up at the dam, raising its effective height by three or four feet. Students would surf the standing wave. More importantly, the three or four feet of river rise provided retention so that the Red Cedar did little damage. Some picnic area got flooded, but that was a lot better than having a destructive torrent. Here’s some more on the benefits of dams.

Between July 31 and Aug 1 the Clinton River rose nine feet in 3 hours, sending 130,000,000 cubic feet of water and sewage to lake St Clair.

Between July 31 and Aug 1 the Clinton River rose nine feet in 3 hours, sending 130,000,000 cubic feet of water to lake St Clair.

The Sierra club supported (supports) my opponent, in part because he supports natural rivers, without dams. I think they are wrong about this, and about their political support in general. Last night, following a 1 1/2 inch rain, the Clinton River flash flooded, going from 5.2 feet depth to 14 feet depth in just two hours. My sense is that the natural state of our rivers had included beavers and beaver dams until at least the mid 1700s. I figured that a few well-designed dams, similar to those at Michigan State would do wonders to stop this. Among the key locations were Birmingham, on the Rouge, Rochester, near Oakland University, Auburn Hills, and the Clinton River gorge, and near Lawrence Technical University. If we could not afford to build man-made dams, I figured we could seed some beaver into nearby nature areas, and let the beavers dam the rivers for free. It would bring back the natural look of these areas, as in the picture below. And engineers at Lawrence Tech and Oakland University might benefit from seeing the original dam engineers at work.

Beaver dam on a branch of the Huron River. Beavers are some of the best dam builders.

Beaver dam on a branch of the Huron River. A rather professional and attractive job at a bargain price.

Beavers are remarkably diligent. Once they set about a task, they build the basics of a dam in a few days, then slowly improve it like any good craftsman. As with modern dams, beaver dams begin with vertical piles set into the river bottom. Beavers then fill in the dam with cross-pieces, moving as much as 1000 lbs of wood in a night to add to the structure and slow the flow. They then add mud. They use their hearing to detect leaks, and slowly plug the leaks till the dam is suitably tight. Most of the streams I identified are narrow and pass through wooded areas. I think a beaver might dam them in a few days. Based on the amount of wood beavers move, and the fact that beavers are shaped like big woodchucks, I was able to answer the age-old question: how much wood would a woodchuck chuck if a woodchuck could chuck wood — see my calculation here.

Me, visiting the DNR to talk beavers

Me, visiting the DNR to talk beavers

There are a few things to check out before I start hiring beavers to take care of Oakland county flooding, and I have not checked them all out yet. Beavers don’t necessarily build where you want or as solidly, and sometimes they don’t build at all. If there are no predators, beavers can get lazy and just build a low-water lodge and a high water lodge, moving from one to the other as the river rises and falls. Hiring a beaver is like hiring an artistic contractor, it seems: you don’t necessarily get what you ask for, and sometimes you get more. Given the flash flooding we have, it’s hard to picture they’d make things worse, but what do I know? In some cases, e.g. the Red Run near the 12 towns drain, the need is for more than a beaver can deliver. Still, without beavers, the need would be for a billion gallons of retention on the Clinton alone, a 10 billion dollar project if carried out as my opponent likes to build. So, with no budget to work with, my next stop was at the Department of Natural Resources Customer Service Center (Lansing). I had some nice chats with beaver experts, and I’m happy to say they liked the idea, or at least they were not opposed. I’ve yet to talk to the Michigan director of dams, and will have to see what he has to say, but so far it seems like, if I get elected in 2020, I’ll be looking for some hard-working beavers, willing to relocate. I’d like to leave it to Beaver.

Robert E. Buxbaum, August 2, 2018. I still don’t get the Sierra Club’s idea of what a natural river would look like, or their commitment to Democrats. In my opinion, a river should include beavers, fish, and fishermen, and drainage should be done by whoever can do it best. Sierra club folks are welcomed to comment below.