Category Archives: politics

IFL Science grows up.

I used to follow an Australian science blog, called “I Fucking Love Science.” Elise Andrew and her crew scanned the literature with a keen eye for the interesting. They regularly posted to Facebook and alerted science nerds like me to all sorts of new science bits with minimal commentary, minimal advertisements, and no politics. On average they found 6 or 8 really interesting posts, per week, generally one or two on fundamental physics, one or two on materials, one or two on biology or medicine, one or two astronomy, perhaps a chemistry post. My post about the color of the sky on Mars was ignited by a picture of the Mars sky that I saw on IFL Science — the sky was yellow, and I had just written about why the sky on earth was blue, and not green.

But, as with all quirky things, this one matured. The name changed to “IFL Science” — a change that I suspect was designed to promote sharing. There were more advertisements, and click bait — “this starlet lost a ton of weight,” “you won’t believe what this famous person’s partner looks like now,” etc. And there was politics, vaguely presented as science. Ms Andrew wrote more and more of herself, making herself into a personality whose travels and speaking tours would interest us. And there were non-science, guest bloggers too: People telling you who to vote for and more importantly who to vote against. All for the good of the world, she said, but it was her opinion, and not what I’d gone to IFL for.

The science got less technical, too and more popular. More pretty pictures and misleading headlines. Currently there is no math, no equations, no chemical diagrams. A top story of this week told of a semi-interesting approach for women with constipation — something that “would change everything.” When you click on the story, you find that women put their finger in their vagina and work out the poop that way, something called “splinting.” It’s sort of science, but not the sort that made me love science. Another top story — the top one from today is as follows:

Top story from IFL science today, Feb 28, 2021. Is there really no fuel use? No. The fuel is a battery, and the speed in 4m/s (9mph), and the plane looks nothing like this.

If you follow the links to here, it turns out that the plane (unmanned) looks nothing like this. It uses electric energy from a battery to move ionized air rearward at an efficiency far lower than with a propeller. The forward speed is 4 m/s (9 mph) and the maximum distance covered was 55m, half a Canadian football field. As presented in IFL science, it’s a misleading, non-math clickbait for something that’s interesting engineering — sort of. As for being Star Trek like, no. To move this plane, you need air.

I’m sorry, you can not make quantum mechanics for dummies. No dummy will understand it. You can make a book that’s not quantum mechanics for dummies, or a quantum book not for dummies. Just saying.

In the treatment of the work of the recent Noble laureates, IFL Science didn’t talk about the work so much as the biographies of the people, and their struggles, and that two of the people who won Nobels for their work in biology were women — for an advance related to CRISPERS– but that wasn’t science. I’d prefer to know what the advance was, and how it works. I’d prefer to figure out that these were women from their names or from the pronouns like, “she” or “her”. There was also no information about other two researchers (males, I assume, or perhaps females who had less-interesting biographies?). It was the same with the Physics Nobel except that I already knew there was a black hole at the center of the galaxy, and that those who found it are long dead. Instead the Note Prize was being awarded for a photograph of the black hole. Interesting (sure doesn’t look like a black hole to me). Is there something they learn from the photo. I’ve noted that we are likely within a black hole, and I show why this is using some, not too difficult math.

Having griped along this way, I have to say that that IFL isn’t that bad, it’s just non-mathy, popular, and a little grown up. That’s sad, but it’s not toxic. Grownups make money, and please customers, and that’s how it goes. To quote a wonderful book, The outsiders, “Nothing gold can stay.” In my own blog, I try to be more math-y, and more science-y. My model is Isaac Asimov, a writer who excited me to love science from when I was 8 to when I entered college, nine years later (1972). He would die of AIDS from a transfusion, 20 years after that.

Robert Buxbaum, February 28, 2021

is a colder world better.

For the last several years it has been claimed that some 98% of legitimate scientists believe it is a major need to reduce CO2 output so as to stop the world from getting warmer. When Trump visited the pope 4 yers ago, the pope would not speak to him expect to hand him his anti-global warming letter he’d written, “Laudato Si” and to tell Trump to get on board to stop global warming. Trump said he would read the letter.

Trump visits the pope, and the pope does not look happy

I’m not a fan of science established by Papal dictate based on an informal poll of experts, especially here where the minority includes some of the greatest minds of the 20th century, and the poll is taken by Al Gore’s science expert, but that’s where we are when it comes to science and politics. I also find it that the pope blames the US for global warming but not China when the the majority of CO2 came from China, a country committed to increasing its use of coal. But be this as it may be — the pope doesn’t blame China for imprisoning Catholics either, most recently the editor of Hong Kong’s most widely read newspaper.

So I thought I take a step back to look at the desirability of making the world colder. Is a colder world a better world? Sad pictures of polar bears are presented in favor of the colder world, but for all I know, polar bears prefer it warm. Their numbers are increasing.

Paul McCarthy lyrics; Hey Jude.

If we had a global climate adjustment knob somewhere, a magic knob allowing you to make the world warmer or colder by turning it right, or left, I doubt the consensus would be to turn the knob left. There is no real logic to cold being good, but there is a line in “Hey Jude”: “…It’s a fool who plays it cool, by making his world a little colder.” And Svente Arrhenius, one of the great scientists of 100 years ago, said he preferred a warm earth to a cold one to avoid disease and starvation. When the climate turns colder, the result is disease and famine as crops fail and animals freeze. It’s not an option that I’d think most people would prefer. given my choice, I would prefer things a little warmer.

I should also note that our ability to fine tune the climate is not what we’d think. The world climate is chaotic, and there is no reliable knob. Historically, the most common setting is ice-age, and that’s a setting that most people really don’t like.

Robert Buxbaum, February 20, 2021.

Chinese billionaires keep disappearing with facebook twitter’s help. Alibaba’s Jack Ma is the latest.

Jack Ma, disappeared billionaire owner of Alibaba.

Every 25 years or so, for the past 1500 years China gets a new dictator who rounds up the rich and famous for loyalty trials, imprisonment. and worse. This was true of Li Ping following Tianamin Square, and Mao Zedong who killed some 75 million as part of his 10,000 flowers, great leap purges. The current dictator, Jenping Xi. Like, has been rounding up anyone he worries about, and that’s basically anyone he might worry about. The latest is Jack Ma, the founder of Alibaba, China’s version of e-bay and Amazon. Until his disappearance, he was the richest person in China.

Ma had not been seen in public since October 2020, when he and two top lieutenants of Alibaba were called to meet with regulators. He reappeared months later in a 40 second video (some say a hostage video) to say he is more rested now, and that he is positive that China’s regulators do not stifle innovation. As typical for China, there is no information about his whereabouts. What’s novel is that US media companies are involved helping Xi to trace potential opposition and keep questions out of the press. This includes Google, Twitter, and Facebook, as well as US media outlets.

71st Cannes Film Festival - Screening of the film "Ash Is Purest White" (Jiang hu er nv) in competition - Red Carpet Arrivals - Cannes, France, May 11, 2018. Fan Bingbing poses.
China’s biggest starlet, Fan Bingbing, vanished from sight and the internet for months. She may have said something critical, but has reappeared and recanted it.

In the past the news and social media would have been full of negative comments about China, and Ma’s detention , both from within and without. Now there is hardly anything and what little there is, is mildly positive about Xi. For three months there have been no e-mail or published tweets or Facebook posts from Ma or his lieutenants. Similarly, there is no room for negative speculation within China, and little within the US. The company’s planned IPO was cancelled, one that could have been the richest in history, but this fact got virtually no press, not in China, not in the US. Regulators cancelled it just two days before the start of trading. You’d expect screams from inside and outside China; instead, the story has been covered only briefly by CNN and the Financial Times, generally putting a pro-China spin on it. They stress the importance of regulations and avoiding monopolies, and don’t mention that Alibaba competes with Amazon, e-bay and Walmart. The expectation is that Ma and his higher-ups will be found guilty of monopoly trading and abuse of power. Under Xi, these crimes that have sent corporate leaders to prison for 12 to 20 years.

Ren Zhiqiang, missing billionaire, sentenced to 18 years.

Consider the fate of Ren Zhiqiang, the 69 year old chairman of Huayuan property conglomerate. It was one of the largest property groups in China, but Ren vanished in March 2020 after being heard to have complained about how the government was handling COVID-19. He was expelled from the communist party, and in September 2020 sentenced to 18 years in jail for “taking bribes and abuses of power.” There was hardly a trial, and as with Jack Ma, Facebook and Twitter helped the party silence Ren and his supporters. The result is that he had no recourse to the court of public opinion. About a month later, Facebook and Twitter did the same to Donald Trump, banning him for life from Facebook, Twitter. All other platforms joined, these included Snap and Reddit. As in China they also banned his main lieutenants and his main supporters, including the my-pillow man. The internet services also closed (deplatformed) Parler, the only competing web-service that allowed Trump and his supporters to post.

It can help to have public outcry, as Xi found after he disappeared China’s most popular movie starlet, Fan Bingbing in July 2018. Fan is a star of Chinese TV and movies and appears in Iron Man II and X-Men. As with Ma and Ren, Facebook and Twitter removed all posts, comments, questions, and complaints about Fan, releasing only the official statement that she was under investigation and taking a break. Unlike Ren, Fan reappeared a year later, April 2019 with no official charges filed. Nor has there been any official report. She has apologized for misdoings. and is supposed to have paid some $150 million, but she’s free. My guess is that the pressure of 100 million Chinese fans is what helped Ms Fan to un-vanish.

Chairman of Anbang Insurance Group Wu Xiaohui attends the China Development Forum in Beijing, China
Had Wu Xiaohui, former chairman of Anbang Insurance Group, and owner to the Waldorf Astoria.

A less positive outcome is when there is no outcry. When Wu Xiaohui, chairman of the Anbang Insurance Group, and the owner of New York’s Waldorf Astoria hotel vanished for two years. When he reappeared, he faced a quiet trial that sentenced him to 18 years in prison. The usual charges: fraud and abuse of power. Wu’s mother claimed she had no access to her son for those two years. Anbang, once one of the largest insurers in China, was taken over by its insurance regulator who has applied to liquidate the company. Why liquidate? Probably because it’s the easiest way to remove potential Wu loyalists.

In the US, there are some claims that Facebook, Twitter, Reditt and a few other companies have too much control of public discourse. Others claim that these companies exercise too little control. These companies claim the right to silence opinion they consider untrue, or inflammatory, and they have been allowed to deplatform their competition. Congress is moving to be in charge of who they silence. I’ve found they don’t like pro-Israel sentiments. While they don’t put words in my mouth, I don’t like it that they take words out of my mouth. As a result, I’ve cut back on my use of these platforms.

Jack Ma reappeared after 3 months in this 40 second video, shot from an unknown location. To me, it looks like a hostage video, “I’m well and being well treated …” Biden has argued that now is the time to move closer to China.

As I write this, Trump is impeached for the second time. The charge is inflammatory speech. Like with abuse of power, there is no way to prove you didn’t do it, especially after the internet giants silence you and anyone stupid enough to support you. Among Biden’s first acts is to undo Trump dictates that kept China from providing the technology underlying the US power and water system. Clearly Biden feels it is important that China should have a hand in this. I surely am not going to suggest that the bribes Biden is supposed to have received from China played any role. I will say that, when I ran for water commission, one of my goals was to help make the water system more resistant to cyber attack.

Dr. Robert E. Buxbaum. February 8, 2021. As an update, I see that Jimmy Li was arrested. He’s the founder of Hong-Kong’s most popular newspaper, Apple daily. No comment in the US, or from the Vatican. Li is Catholic, and the Vatican used to chime in when prominent Catholics were arrested.

New York and San Francisco rents fall, Detroit rises for now.

Rents in New York and San Francisco are far less expensive than before the pandemic. It’s been a boon for the suburbs, the south and the midwest, one that’s likely to continue unless Biden steps in. Before the pandemic, rent in San Francisco for a one bedroom apartment averaged over $3700 per month. New York rent was similar. People paid it because these cities offered robust business and entertainment, the best restaurants and bars, the best salons and clubs, the best music, museums, universities, and theater. New York was Wall Street, Madison Avenue and Broadway; San Francisco was Silicon valley and Hollywood. These cities were the place to be, and then the pandemic hit.

Post COVID-19, the benefits of big city life are gone, and replaced by negatives. The great restaurants are mostly gone; the museums, theaters, and salons, shut along with Hollywood. Wall Street and Madison Ave have gone on-line, as have the universities. If you can work and study from anywhere, why do it from an expensive hotbed of Corona.

People of means left the big cities with the first lockdowns. Wall Street moved on line, with offices in New Jersey, and many followed, along with college students, and hotel and restaurant workers. New York’s unemployment rate increased from 4-5% to over 9.5% today, among the highest rates in the nation, 9.5%. It would be higher if not for the departures. Crime spiked; the murder rate doubled. To keep people from leaving, landlords have lowered rents and many will now forgive a month or two of rent to keep apartments full with some rent coming in and an illusion of exclusivity. This is good for tenants, but tough on landlords.

Detroit rent history, 2014 to January 2021. Rents fell a lot on election day, maybe because of Biden, or because we think the pandemic is over.

As things stand, the suburbs and smaller cities are the beneficiaries of the exodus. Among the cities benefiting the most are cities in the south and mid-west: states that are more open and are relatively low cost: Phoenix, Oakland, Cleveland, St. Petersburg, and even Detroit. Detroit’s rents were already moving up as auto manufacturing returned from Mexico, see chart. Between early 2017 and October 2020, they went from $500/month to $1250/month for a 1 bedroom apartment, according to Zumper. Detroit rents fell after election day, but are still up 20% on the year. The influx of wealthier working folk to Detroit is welcome to some, unwelcome to tenants who find their rents are raised. I think it’s is a sign of a healthy economy that people follow life-quality, and that rents follow people. Our landlords are happy, but there are a lot of Detroit renters who are not

Joe Biden has promised to step in to make things right for everyone. He promised to have the government pay people’s rent so they don’t get evicted. I presume that means paying about double to people in NY and SF as to those in Detroit. He claims he will shutter smokestack industries too, and create the good jobs of the future in computers and high tech. It’s a nice claim. I suspect it’s a bailout of big city landlords, but what would I know. I suspect that the US would be better off if Joe just sat back and let New York rents fall, while allowing Detroit to gentrify. Detroiters need not worry about rents getting too pricy here. We’ve1500 shootings per year, that 15 times more than NYC, per capita. Unless that ratio changes, Detroit will continue to be the lower rent city.

Robert Buxbaum, January 17, 2021.

MI hunting: You can arm bears; you just can’t buy bullets.

Large chunks of Michigan shut down for the prime days of hunting season, from the middle of October to early November. About 8% of the state gets a hunting license each year, some 800,000 people, all trying to “Bag a buck.” Michigan is an open carry state for rifles and holstered pistols, something seen recently in the state capitol, I’d say this was an illegal example since there is also a brandishing law, but it gives a sense of things here. About 29% of the state owns at least one gun, and usually more. There are about as many guns as people. Getting bullets, on the other hand, is near impossible, both for handguns and for most rifles, shotguns excluded.

A lot of the attraction of hunting is that you get to eat what you kill. Mot people do this or donate it to a food back. Hunting is also cheaper than golf. Rural farmers also hunt to protect their crops from crows, squirrels, rabbits, rats, snakes, and raccoons. This is legitimate hunting, in my opinion, even though you typically don’t eat crow. Some people do hunt bear, but that’s a different story (I like to be dressed). It’s possible that the bullet shortage is just a hiccup in the supply chain, “supply and demand” but it’s been going on for 12 years now so I suspect it’s here to stay.

Michigan, was once a Republican, pro-gun stronghold. It has swung Democrat and anti-gun for the last few years. Bulletes have been scare for about that long, at least since the Obama election or the Sandy Hook shooting. Behind this is a general trend of urbanization and class-action law suits. At this point, few sporting stores carry guns or bullets, and those that do, tend to hide them in a back room. Amazon carries neither bullets nor guns, and the same holds at e-bay, Craig’s list, and Walmart on line. Dunhams still sells guns but the only bullets, when I visited today were, 17 caliber, 227 and duck-hunting, shotgun shells. Gone were normal handgun calibers: 22, 25, 32, 38, 45, 357, and 9mm. The press seems OK with duck or moose hunting; not so OK with anything else.

The salesman at Dunham’s said that he had moved to bow hunting, something that’s becoming common, but it’s incredibly difficult even with modern bows. I can rarely hit a non-moving target at 50 feet on the first arrow, and I can only imagine the frustration of trying to hit a moving target after sitting in a cold blind for days waiting for one to appear whose distance and placement is unknown, and that might disappear at any moment, or attack me then disappear.

Part of the problem is that arrows travel at only about 250 ft/s, or about 1/6 the speed of a bullet. Thus, an arrow fired from 50 yards takes about 0.6 seconds to hit. In that time it drops about 6 feet and must be aimed 6 feet above the deer if you hope to hit it. A riffle bullet falls only about 2 inches, about 1/36 as much. Whaat’s more, though an arrow is about three times heavier than a hunting bullet, its slow speed means it hits with only about 1/10 the kinetic energy, about the same as hunting with a 22 from a handgun.

There are those who say the bullet shortage will go away on its own because of supply and demand. That’s true until the government steps in in the name of public safety. Though recreational marijuana and moonshine are both legal, government regulation means that prices are high and supply is limited, with a grey market of people buying high and selling higher. I’m seeing the same with ammunition; there is tight supply, a grey market, and a fair number of people trying to reload spent ammunition using match-tips for primers. Talk about white lightning.

R. E. Buxbaum, December 24, 2020.

A pacifist’s personal protection, a 22 revolver.

Before a pacifist buys a gun, there are two critical questions to ask: One is ‘how would I feel if I killed a criminal?” The other is ‘how would I feel if I missed and killed someone else? In my case, I’d feel awful either way. My thinking, even with the criminal, is that I tried my best to do more good than bad, and part of that is to minimize the chance of killing needlessly. Statistics suggest that gun carrying, in general, does good by deterring violent criminals. To be able to stop a deadly attack, while minimizing the chance of killing– particularly an innocent bystander — I’m inclined to a low power gun that’s easy to conceal and easy to aim well. This leads me to suggest a 22 revolver with a barrel that’s not too long to conceal, nor too short for good aiming, 2.5-4″ seems ideal.

An analysis of what percent of people stop attacking when hit by one bullet of different calibers. The 32 and shotgun are the best, in part because the shooter tends to stop shooting at one shot. With a 9 mm, the shooter keeps on shooting, likely doing more damage than necessary.

At this point I’d like to say that I am not a gun expert. I’ve fired perhaps 15 guns in my life including 5 revolvers. The easiest of these to shoot was a Glock 9mm, heavy, large and powerful, but it think it would be too large to carry or draw in a deadly situation, and the Glock was not cheap. The 22s were all smaller guns, and the 22 cartridges, especially the 22lr, are dirt cheap, costing 8 to10¢ each, or $40-$50 for a box of 500. It’s not the 9mm are super expensive, but they cost 25-30¢ each or $25 to $30 for a box of 100. The price is higher today, over $1 each, because of an ammo shortage, but it’s coming down.

Another advantage of the 22 is that the kill power is lower. A 9mm round will go through the person you are shooting at, and kill the person behind, and can kill on a riccoshet. I like that the 22 won’t do this. I also like that the 22, more effective than almost any other round at stropping a criminal, and getting him to go away. As the chart above shows, there is a 60% stop after the perpetrator is hit once, and that’s my goal — getting him to go away. A shotgun is far more effective as a deterrence, over 80%, but it is much more likely to kill, and much harder to conceal carry. The chart above is from a wonderful analysis of the effect of different calibers used in crimes, read it here. The author, Greg Ellifritz, suggests that the reason the 22 is so effective at stopping a criminal is psychological: criminals stop if shot even once, especially from a civilian, and only civilians use 22s. Larger calibers are better appear to be less effective, though they will be better at stopping a really determined attacker, e.g. someone on PCP. But that’s not the environment I work in, and I suspect it’s not the majority of crime. Overall, one shot from a 9mm does not do a good job stopping an attacker. Another good option is a 32. It was the choice of Theodore Roosevelt and J. Edgar Hoover. It tends to be used by detectives and other professionals, but the bullets are expensive.

I’ve done a meta-analysis of Greg Ellifritz’s death data, and confirm that the 22 is the second least deadly of all bullet types, after the .25. Of 154 people hit with 22 bullets, there 28% fatalities, 43 deaths. The 9mm is more deadly: of those hit with a 9 mm bullet, 44% died, in part because people shooting 9mm tend to shoot more bullets, nearly twice as many as 22 shooters in danger situations.

It takes two hands to cock a semi-automatic, that is to draw the first round into the chamber. Gif from ammuniotndepot.com

Handguns for 9mm rounds tend to be semi-automatic with light triggers and large magazines. Guns for 22 tend to be revolvers with heavier triggers and small loads, 5 to 7 rounds. I suspect that a light trigger leads to more missed shots and misfires, and I notice that many folks with semiautomatics, find they jam in danger situations. In the famous duel between Hamilton and Burr, Hamilton hit the branch above Burr’s head, likely because he’d set his trigger very light. Burr’s trigger was set heavy, and he shot straight. When you are nervous, gun with a light trigger can go off early and miss or kill the wrong person. A lot of the people killed with guns in Detroit, I notice, were killed by mistake, because the shooter missed, or because of a ricochet (I did an analysis of Detroit crime early on in this blog). A ricocheting 22 has very little kill power left.

A single action revolver requires cocking by that can be done with one hand; a double action doesn’t need any cocking. Gif from ammuniotndepot.com

Every semi-automatic I’ve tried required a two handed, “racking” step, see above. Thus, unless you leave a cartridge in the chamber while walking around, you need two free hands and an extra second or two to rack the first bullet before you can shoot. That’s OK on a range, but in a danger situation racking is a problem. Even trained policemen with semi-automatics have been killed by knife-wilding criminals because the criminal didn’t need the extra second or two while the policeman racked the first round.

Racking takes strength and coordination, plus an awareness of legal isuess. If you rack too soon and the situation de-escalates, you could be charged with “brandishing.” In most states it’s illegal to brandish a weapon in a non-deadly situation. You have to wait with your gun in your pocket or holster until you are in mortal danger. With a revolver, you don’t need to rack. Even a single action revolver can be cocked with one hand while the weapon is in your pocket. See the process in the figure above. Double-action revolvers don’t require cocking, and that can be a plus. On the other hand, I figure that the sound of a gun cocking might be useful to signal to a criminal that you are serious without getting you into the problems of brandishing.

De-cocking a single action revolver.

Revolvers have another interesting plus in that it’s easy to un-cock revolver, even using one hand, see gif. With semi-automatic pistols, there rarely a graceful way to remove the bullet from the chamber, certainly not with one hand. In theory, you can shoot from your pocket too; it’s something I’ve seen in the movies, but a semi-automatic will almost certainly jam if you try. If the assailant grabs your arm, or otherwise attacks you, you have every right to fire, but you don’t want a jam, or to hit yourself. Most defensive shootings are from close range.

Speaking of jamming, even experts get jams on a fairly regular basis, and beginners have this problem a lot. They forget to hold the gun tightly enough, or they buy rounds that don’t quite match the gun. Rounds that are too weak or powerful cause problems for semi-automatics. I’ve never seen a revolver jam, and if the round doesn’t fire, you can click again, and another round will appear. With a semi-automatic, clearing a jam is a lot of work: more than I can expect in a danger situation.

I should mention that the folks from ammunition depot, the place I got the gifs, recommends 9mm semi-automatics for personal protection because of the extra “stopping power”. Read their opinion here. I disagree, and here is one last reason: Like many other suppliers, they are out of 9mm cartridges, and have been for months. Perhaps it’s panic buying like with toilet paper, or a manufacturing disruption; 22 lr cartridges are still in stock. Supply problems will likely go away, but it’s another reason to look at the 22.

Robert Buxbaum, December 11, 2020. Some vocabulary words: a bullet is the projectile that comes out the barrel. A round = a cartridge. It’s the thing that you put in the gun before shooting. There are several 22s, all with the same size (diameter) bullet, 0.223″ OD, but with different lengths and power, from short to wmr. Different guns can use different cartridges. Meir Kahane was killed by a 22, as was Bobby Kennedy.

Aspirin protection from heart attack and COVID-19 death.

Most people know that aspirin can reduce blood clots and thus the risk heart attack, as shown famously in the 1989 “Physicians’ Health Study” where 22,000 male physicians were randomly assigned to either a regular aspirin (325 mg) every other day or an identical looking placebo. The results are shown in the table below, where “Myocardial Infarction” or “MI” is doctor-speak for heart attack.

TreatmentMyocardial InfarctionsNo InfarctionTotalfraction with MI
Aspirin13910,89811,037139/11,037 = 0.0126
Placebo23910,79511,034239/11,034 = 0.0217

Over the 5 years of the study, the physicians had 378 MI events, but mostly in the group that didn’t take aspirin: 1.28% of the doctors who took aspirin had a heart attack as opposed to 2.17% for those with the placebo. The ratio 1.28/2.17 = 0.58 is called the risk ratio. Apparently, aspirin in this dose reduces your MI risk to 58% of what it was otherwise — at least in white males of a certain age.

A blood clot showing red cells held together by fibrin fibers. Clots can cause heart attack, stroke, and breathing problems. photo: Steve Gschmeissner.

Further study showed aspirin benefits with women and other ethnicities, and benefits beyond hear attack, in any disease that induces disseminated intravascular coagulopathy. That’s doctor speak for excessive blood clots. Aspirin produced a reduction in stroke and in some cancers (Leukemia among them) and now it now seems likely that aspirin reduces the deadliness of COVID-19. Data from Wuhan showed that excessive blood clots were present in 71% of deaths vs. 0.4% of survivors. In the US, some 30% of those with serious COVID symptoms and death show excessive blood clots, particularly in the lungs. Aspirin and Vitamin D seem to help.

.The down-side of aspirin use is a reduction in wound healing and some intestinal bleeding. The intestinal bleeding is known as aspirin burn. Because of these side-effects it is common to give a lower dose today, just one baby aspirin per day, 81 mg. While this does does some good, It is not clear that it is ideal for all people. This recent study in the Lanset (2018) shows a strong relationship between body weight and aspirin response. Based on 117,279 patients, male and female, the Lanset study found that the low dose, baby aspirin provides MI benefits only in thin people, those who weigh less than about 60 kg (130 lb). If you weigh more than that, you need a higher dose, perhaps two baby aspirin per day, or a single adult aspirin every other day, the dose of the original doctors study.

In this study of COVID patients, published in July, those who had been taking aspirin fared far better than those who did not A followup study will examine the benefits of one baby aspirin (81 mg) with and without Vitamin D, read about it here. I should note that other pain medications do not have this blood-thinning effect, and would not be expected to have the same benefit.

While it seems likely that 2 baby aspirins might be better in fat people, or one full aspirin every other day, taking a lot more than this is deadly. During the Spanish flu some patients were given as much as 80 adult aspirins per day. It likely killed them. As Paracelsus noted, the difference between a cure and a poison is the dose.

Robert Buxbaum, November 27, 2020.

Locked down so long, it’s looking up: the up-side of COVID-19.

I’m not crazy about the COVID isolation, but there are up-sides that I’ve come to appreciate. You might too. Out of boredom, I was finally got into meditation. It was better than just sitting around and doing nothing.

It’s best not to look at isolation as a problem, but an opportunity. I’ve developed a serious drinking opportunity.

And it’s an opportunity to talk to myself. I told myself I’ should quit drinking. Then I figured, why should I listen to a drunk who talks to himself.

A friend of mine was on drugs, but then quit. Everyone in his house is happy, except for the lamp. The lamp won’t talk to him anymore.

The movies are closed, and the bars, and the gyms. It gives me another reason not to go to the gym.

Did you know that, before the crowbar was invented, crows used to drink at home.

The real reason dogs aren’t allowed in bars: lots of guys can’t handle their licker.

There’s time to spend with my children. And they look like me.

I like that I don’t commute. Family events are over zoom, funerals (lots of funerals), meetings, lectures. They come in via the computer, and I don’t have to dress or attend. No jacket, no pants… no travel …. no job.

My children are spending more time with us at home. We have virtual meals together. I discovered that I have a son named Tok. He seems to like my dad-jokes.

My wife is finding it particularly tough. Most every day I see her standing by the window, staring, wondering. One of these days, I’ll let her in.

I asked wife why she married me. Was it for my looks, or my income, or my smarts. She smiled and said it was my sense of humor. 🙂

My wife is an elementary school teacher. She teaches these days with a smart board. If the board were any smarter, it would go work for someone else. It’s necessary, I guess. If you can’t beat them, you might as well let the smart board teach. I think the smart board stole the election. It began by auto-correcting my spelling. Then it moved to auto correct my voting. The board is smarter and better than me (Hey, who wrote this?)

some mask humor
I’ve learned to love masks, though some of them are hot.

You’d think they’d reduce the number of administrators in the schools, given that it’s all remote. Or reduce the price of college. It would be nice if they’d up the number of folks who can attend. So far no. Today the Princeton alumni of Michigan is sponsoring video-talk by Princeton alumnus, George Will. I wanted to attend, but found there was limited seating, so I’m on the waiting list (true story). By keeping people out, they show they are exclusive. Tuition is $40,000 / year, and they keep telling us that the college is in service of humanity. If they were in the service of humanity, they’d charge less, and stream the talk to whoever wants to listen in. I have to hope this will change sooner or later.

Shopping for toilet paper was a big issue at the beginning of the pandemic, but I’ve now got a dog to do it for me. He goes to the store, brings it back. Brings back toothpaste too. He’s a lavatory retriever. (I got this joke from Steve Feldman; the crowbar joke too.)

I don’t mind that there are few new movies. There are plenty of old movies that I have not seen, and old TV shows too.

This fellow is the new head of Biden’s COVID-19 task force. He’s got a science-based plan for over-population and the disease.

I like that people are leaving New York and LA. It’s healthy, and saves on rent. Folks still travel there, mostly for the rioting, but lockdowns are nicer in Michigan.

More people are hunting, and hiking, and canoeing. These are active activities that you can do on lockdown. The old activities were passive, or going out to eat. Passive activities are almost a contradiction in terms.

We’re cooking more at home, which is healthier. And squirrel doesn’t taste half bad. If I live through this, I’ll be healthy.

I’m reading more, and have joined goodreads.com. I’ve developed a superpower: I find can melt ice cubes, just by looking at them. It takes a while but they melt.

A lot more folks have dogs. And folks have gotten into religion. Wouldn’t it be great, if after death we fond that dyslexic folks were right. There really is a dog.

Let’s love the virus. If we don’t, the next crisis will be worse.

There was an election last week. My uncles voted for Biden, which really surprised me. They were staunch Republicans when they were alive. My aunt got the ballot and convinced them. She was a Democrat when she was alive.

I got pneumonia vaccine shot, and a flu shot. That wasn’t a joke. I think it’s a good idea. Here’s why. People mostly die from pneumonia not the virus.

Before COVID, the other big crisis was global warming. Al Gore and Greta Thunberg claimed we had to shutter production and stop driving to save the planet. COVID-19 has done it. The next crisis is over-population. COVID is already curing that problem — not so much in China, but in the US, Europe, and South America.

Just As a final thought, let’s look at the bright side of the virus. If we don’t, the next crisis will be worse. Take Monty Python’s advice and Always look at the bright side of life.

Robert Buxbaum, November 20, 2020.

Tale of a fast, accurate home COVID test

My son works at a company called Homodeus. It’s part of 4Catalyzer, an umbrella of seven medical biotechnology companies with a staff of 300 scientists and engineers. One of the Homodeus products, still waiting FDA guidance is a COVID-19, RNA self-tester called Homodeus Detect. It tests for COVID RNA directly, not for antibodies, with tests are much faster than hospital tests, taking 45 minutes, but more complex than the unreliable test strips. So far, the Detect tests have shown no false positives or false negatives. That would suggest 100% reliable, except but there are a fair number of invalid tests. The invalid tests are lares due to the complexity, and also to the fact that you are testing snot, essentially. There is no blood-taking involved, unlike with the test strips, but  just a nasal swab, and the cost is moderate, about $35 per test. However you have to do some lab work. After you swab your nose, you put the swab in a heated liquid bath where chemicals break up the snot and dissolve the shells on any viruses or pollen present. After 30 minutes, you pass the liquid onto a detector strip that contains a conjugate protein that binds to SARS-CoV-2 RNA. Your answer appears 15 minutes later as one of three lines: one for positive, one for negative, or one indicating an invalid test. Invalid tests show up more often than they like, about half the time, especially when the test is done by amateurs. 

Getting an invalid test result is a downside of the current product, but I don’t think it should prevent sales. You get better at doing the test, and speed and lack of false positives and negatives is a bigger plus. It seems worthwhile to fast-track offer this test for doctors offices and hospital admissions, at least. I’d also like to see it used for airplane boarding and interstate travel, so that a person traveling might avoid the two week quarantine that many states impose. I’d certainly pay $200 or more to avoid a two-week quarantine, and if I have to do a second or third test, I’d do that too. 

At least some people realize it’s a big advantage to know if you are currently infections.

Because this test measures virus RNA, and not antibodies, it indicates infection virtually as soon as you’re infected. That’s a benefit for those wishing to fly, or to meet with people, an advantage that is not lost on Elon Musk at least (see tweet). The test also shows negative as soon as the virus is gone, and that’s big. In recent months the FDA has fast-track approved an antibody indicating test from Abbott Labs, but that test has many false readings and only indicates infection several days afterward, and it does not indicate when you are no longer infectious. 

The FDA has not offered to fast track this test, or any other like it for approval. They have not even indicated what sort of reporting and privacy requirements they want, so things sit in limbo, both for Homodeus, and for competing companies. Here is a story in USA today: https://www.usatoday.com/story/news/2020/07/29/fda-opens-door-rapid-home-covid-19-tests/5536528002. One big issue that the FDA is contact tracing. The FDA would like to be able to trace all the contacts of anyone who tests positive, while maintaining privacy as demanded by the 4th Amendment.

One way around the 4th amendment concerns would be to require anyone who uses the test to sign a waiver allowing the government to trace their contacts. Alternately there could be a block-chain enabled app that would come with the test. An app coms already providing a timer for when to move to the next step, and it includes a machine-vision system to help analyze dim lines on the indicator. Perhaps the FDA would accept block chain as a way to allow full reporting while maintaining privacy The FDA has yet to provide guidance on what they want, though. Without guidance or fast-track approval, things sit in limbo. Here is a scathing legal analysis from the Yale Law Journal.

You can get a free test, but have to do it at Homodeus headquarters in Guilford, Connecticut. It’s free, and results appears in about 45 minutes.. Homodeus has been manufacturing the test in quantity; if you are interested, use the following link to sign up: https://www.homodeusinc.com/research. Healthcare providers are particularly welcome.

The Homodeus detect test kit. Picture from this article in the New Haven Register.

Why did the FDA fast-track approve Abott’s antigen/ antibody test. Maybe because the tests rethought to not lead to lower mask use. Alternately, Abott has more political pull. You can read the FDA’s explanation here. In my biassed opinion the Homodeus product is good enough to fast track especially for hospitals and healthcare providers. It could save lives while allowing the economy to reopen.

Robert Buxbaum, November 15, 2020 (with massive help from Aaron M. Buxbaum)

When was America great last? Before October 24, 1945, United Nations Day.

Last night a CNN reporter was going around a Trump rally asking ‘When was America ever great?” It’s a legitimate question for anyone wearing a MAGA hat. “Make America Great AGAIN” suggests that America was once great and is no more. The answer the reporter pushed for, I think, was the one given by NY’s Governor Cuomo: “America was never that great.” Alternately, the answer of Michelle Obama, who claimed in 2008, “For the first time in my adult life, I am really proud of my country.” The attendees attempted other answers, like 1776, but the reporter shot them down, saying that people were enslaved in 1776, and telling the home audience that even later, women didn’t have the right to vote, or the LGBT community was denied the rights to which it was entitled. I was not there, and might have got shot down too, but I suspect the question deserves an exact answer: the last time America was great was just before October 24, 1945, United Nations Day, the day we submitted to be part of a world government.

Jackie Robinson, the first black American in major league baseball. Signed October 23, 1945.

By October 23, 1945 WWII was over. We had peace and plenty, the most powerful military, and the most powerful economy. Besides this, we had a baby boom (Children are a bedrock of success, IMHO). Also, on October 23, 1945, the Brooklyn Dodgers signed Jackie Robinson, the first black, major Leaguer since the late 1800s. We thus took a major step against the greatest of our original sins. These were aspects of US greatness, but they were were not guaranteed. They were based on two pre-requisites: a national dedication to self-improvement, and the sovereign control we had over our self-improvement. Total control ended on October 24, 1945 when we joined with the Soviet Union, the United Kingdom, China, France, and several other nations accepting (limited) control by the United Nations organization.

By accepting United Nations oversight, we gave over a significant chunk of sovereignty to other countries whose desire, mostly, was that the US should not be greater than them, and largely that it should not be great at all. To that end they endeavored to insure that we did not have the most powerful economy, the most powerful military, or a baby boom. From tat day on, other countries would sit in judgment on our behaviors and goals. More and more, they would demand remedies that served their interests and diminished US greatness, its exceptionalism. To the patriot this is a disaster. The New York Times declares that anti-exceptionalism is the road to world peace and prosperity. The MAGA crowd disagree.

The United Nations officially came into existence on October 24, 1945, after the United States, the Soviet Union, the United Kingdom, China, France ratify the UN Charter. The charter, once signed, was handed to Truman’s assistant, Alger Hiss.

It’s not that the MAGA Republicans are against world peace or prosperity. No sane person is, but they claim that the best way to achieve these things is for us to be exceptional and work in our own best interests. It is only a sad peace that is achieved by having a foreign body decide that we are at fault in every conflict, and that we should pay reparations to all who lag. There are many poor, socialist countries choosing judges, and these judges tend to rule that the US, as a rich nation, is always at fault and should always pay — both for “development” of the poor nations -overseen by them — and for the the UN too. We knew that their judges would rule this way, but likely didn’t care, or realize how much of our greatness rested on sovereignty. Without sovereignty, even the greatest of world powers will be brought down. Alger Hiss, the person Truman handed the signed UN charter to, was a spy for the Soviet Union. It was a telling beginning.

One of the big promises of Donald Trump is that he will limit the reach of the UN and of its ability to reach into our pockets. He already renegotiated or rejected trade agreements, like TPP that would have sent our jobs and technology abroad. Trump also placed import taxes (tariffs) on some foreign goods. The MAGA folks approve, but the Obama internationalists are scandalized. As depicted in the book “Fear”, long time (Obama) staffers at the White House stole tariff bills from the president’s desk to save the world by keeping them from Trump’s signature. Tariffs have been used throughout American history, and can be a benefit for jobs, and diplomacy and for American manufacturers. They are not radical, but some people lost out. Larely, those were US consumers of foreign goods who suffered. Things improved most for black and hispanic workers though. The intellectual class who claim to represent black and hispanic interests have removed Trump and supporters from social media. It’s their way of winning the argument.

Henry Cabot Lodge, Wilson’s main opponent ito the US joining the League of Nations,.

A major anti-MaGA goal is to stop global warming. This is done by globe-trotting folks in private jets who’ve agreed we should shut US industry and pay $1B/ year, while permitting unlimited coal use by China and India. They were the largest CO2 sources, and also among the least efficient producers.Their share of CO2 output is huge and growing. The globe-watchers don’t care. By the way, is a cold world is something we really need?

Trump also limited the power of the world trade organization and of the world court. It’s something that Henry Kissinger recommended In the Journal “Foreign Affairs 2001. Kissinger wrote that “The danger [in too much power for the world court] consists of substituting the tyranny of judges for that of governments; historically, the dictatorship of the virtuous has often led to inquisitions and even witch-hunts.” Trump also built up the military, and claims he will eliminate a postal agreement that gives low, subsidized rates, to China and poor countries so they can mail goods to the US for far less than we can to ourselves. Joe Biden has pushed for “the dictatorship of the virtuous” and promises to raise taxes to pay for it. He’s also suggested packing the supreme court. To me, this is far more radical than tariffs.

The MAGA divide between Trump and Obama/ Biden is not new. It’s existed to a greater or lesser extent between most Democrats and Republicans as far back as the civil war. One major cause of the civil war was tariffs. Then as now, tariffs benefit the manufacturer and worker, and hurt the aristocrat.

In 1918, the MAGA divide played flared because of Wilson’s support of the League of Nations. Republican, Henry Cabot Lodge opposed joining the League of Nations over the same complaints that Trump has raised. Trump’s MAGA claim is that he’ll make US agreements serve US interests. Also that he’s making the US military strong again, and making the US economy strong again. For all I know, the plan for the next four years is to try to ignite another baby boom, too. This, as I understand it, is the MAGA message.

As a side issue, I note that virtually every rapper is for Trump, and virtually every orthodox rabbi too. Yet the internationalist claim he’s racist. His approval among black voters is polled at 46%. Unless you hold that Jewish and black voters don’t understand their own interests. it would seem that Trump is not the racist he’s claimed to be. A recent, “jews for Trump” parade in NY was attacked with rocks, eggs, fists, and paint thrown on participants by white Democrats. The racists who run the NY Justice Department decided not to prosecute.

Robert Buxbaum, October 27-28, 2020. I figured it was time someone explained what “Make America Great Again” meant. I’ve also speculated on Trump’s religion here, and on his mental state, here.