The main building block of Alzheimer’s research was faked. Now, what.

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Much of health research is a search for simple, bio-molecular causes for our medical problems. These can result in pill-solutions. Diseases tend to be more complex, but Alzheimers seemed to work that way, until this summer when it turned out that the data supporting the simple theory was faked. Alzheimer’s is a devastating cognitive disease that is accompanied by a degenerating brain, with sticky, beta-amyloid plaques and tangles. About 16 years ago, this report, published in Nature seemed to show that a beta-amyloid, Aβ*56, caused the plaques and caused cognitive decline independent of any other Alzheimers indicators. 

The visual difference between an Alzheimer brain and a normal brain is that the former has shrunk. Maybe fat is relevant, fat body leads to a fat brain, and less AZ, maybe?

We were on the way to a cure, or so it seemed. Several studies by this group backed the initial results, and much of Alzheimer’s research was directed into an effort to fill in the story, and find ways to reduce the amount and bonding of this amyloid and others like it. Several other groups claimed they could not find the amyloid at all, or show that amyloids caused the symptoms described. But most negative results went unpublished. The theory was so satisfying, and the evidence from a few so strong, that the NIH poured billions into this approach, over $1B in this year alone. The FDA approved aducanumab, a drug from Biogen, on the assumption that it should work, even though it showed little to no benefit, and had some deadly side effects. Other firms followed, asking for approval of related anti-amyloid drugs that should work.

When news of the fraud came out, detected by Matthew Scragg and a few lone curmudgeons, stock prices plummeted in the drug companies. It now appears that the original work was made up, presented to journals and to the NIH using photoshopped images. For the group that did the fake work, it may mean jail time, for most other groups, the claim is that their work is still relevant. Doctors still prescribe the medications as they have nothing better to offer (Aducanumab therapy costs $50,000 per year). Maybe it’s time to start looking at alternative approaches and theories, sidelined over the last 16 years.

Some alternative theories posit that another molecule is responsible, particularly tau, associated with the tangles. Another sidelined theory is that amyloids are good. For example, that it’s the loss of soluble amyloids that causes Alzheimer’s. Alternately, that inflammation is the root cause, and that the amyloid plaques and tangles are a response to the inflammation, a bandage, perhaps. These theories could explain why the anti-amyloid drugs so often resulted in patient death.

It could be that high bmi protects from dementia. Either that or the diseases that cause weight loss cause dementia. It’s debated here.

It’s also possible that the inability of nerve cells to dispose of waste is the cause of AZ. In heathy people, waste is removed through acidic enzymes within lysosomes. Patients with decreased acid activity have a buildup of waste that includes amyloids. Perhaps the cure is to restore the acid enzymes.

My favorite theory is based on statistical data that shows that fat people are less likely to develop Alzheimers. This might lead to a junk-food cure. The fitness industry is very much against this theory–It’s debated here. They tend to support the inflammation model, claiming that diseases cause Alzheimer’s and cause patients to loose weight first. Could be. I note that Henry Kissinger is the only active politician of my era, the early 70s, still alive and writing intelligently.

Robert Buxbaum, November 17-19, 2022. I hope that Matthew Schragg comes out OK, by the way. Ben Franklin pointed out, that “No good deed goes unpunished.”

Transparent, super wood

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As mentioned in a previous post, wood is more among the strongest materials per unit weight, making it ideal for table tops and telephone polls. On a per pound basis, most species of wood are more than twice as strong as aluminum or mild steel. Wood’s structure is is the reason; it’s a natural composite of air-filled, aligned tubes of crystalline cellulose, held together by natural glue, lignin.

In terms of raw strength though, pounds/in2, wood is not particularly strong, only about 7000 psi (45MPa) both in tension and compression, about half the strength of aluminum. It is thus not well suited to supporting heavy structures, like skyscrapers. (I calculate the maximum height of a skyscraper here), but wood can be modified to make it stronger by removing most of the air, and replacing it with plastic. The result is a stronger, denser, flexible composite, that is typically transparent. The flower below is seen behind a sheet of transparent wood.

A picture of a flower taken through a piece of transparent super-wood.

To make a fairly strong, transparent wood, you take ordinary low-density wood (beech or balsa are good) and soak it in alkali (NaOH). This bleaches the wood, softens the cellulose, and dissolves most of the lignin. You next wash off the alkali and soak the wood in a low viscosity epoxy or acrylic. Now, put it in a vacuum chamber to remove the air — you’ll need a brick to hold the wood down in the liquid. You’ll see bubbles in the epoxy as the air leaves. Then, when the vacuum is released, the wood soaks up the epoxy or acrylic. On curing, you get a composite strong and transparent, but not super strong.

To make the wood really strong, super-strong, you need to compress the uncured, epoxy soaked wood. One method is to put it in a vice. This drives off more of the air and further aligns the cellulose fibers. You now cure it as before (you need a really slow cure epoxy or a UV-cure polymer). The resultant product have been found to have tensile strengths as high as 270 MPa in the direction of alignment, over 40,000 psi. This is three times stronger than regular aluminum, 90 MPa, (13,500 psi). It’s about the strength of the strongest normal aluminum alloy, 6061. It’s sort of expensive to make, but it’s flexible and transparent, making it suitable for space windows and solar cells. It’s the lightest flexible transparent material known. It’s biodegradable, and that’s very cool, IMHO. See here for a comparison with other, high strength, transparent composites.

Robert Buxbaum, November 10, 2022. I think further developments along this line would make an excellent high school science fair project, college thesis, or PhD research project. Compare different woods, or epoxies, different alkalis, and temperatures, or other processing ideas. How strong and transparent can you make this material, or look at other uses. Can you use it for roof solar cells, like Musk’s but lighter, or mold it for auto panels, it’s already lighter and stronger, or use it as bullet-proof glass or airplane windows.

Is the right the source of antisemitism in America.

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Hillary Clinton famously called Trump supporters “a basket of deplorables” and went on to explain that half of them were “unredeemable”, Nazis and Klansmen, while the other half “needed reeducation.” Her statement was applauded on the left, and taken as an insult on the right. To this day, Biden and his group make the claim that Republicans are antisemites and a threat to American democracy. The proof here is a 2017 video of Klansmen carrying torches, saying “Jews will not replace us,” as they protested the removal of a statue of Robert E. Lee in Virginia. A further claim is that the rise in antisemitic incidents, shootings, beatings, etc., are the result of Trump and the Republicans. Things are not quite so black and white, or course, e.g. during the ANTIFA protests/riots four synagogs were attacked in LA alone, and the Crown-Heights neighborhood of Brooklyn was torched. Many of the attackers of Jews have Islamic names and left association, things that don’t suggest Republicans but Democrats.

CNN has claimed that the difference is intent: Trump’s intent is evil, while ANTIFA’s is to elevate black and Moslem lives by allowing them to vent their righteous anger (on Jews). The Moslems who attacked Jews in Monsey, India, Paris and elsewhere are acting for justice, while the marchers in Charlottesville march for hate. In a special program on “Antisemitism in American”, CNN made the claim that no Jew should support the Republicans or Jewish Israel, an apartheid, colonial occupation in their view. This appears to be the view of the Biden White House too. They have yet to congratulate the winner of Israeli presidential elections, 5 days after the election. They contacted Mahmoud Abbas, the Palestinian leader instead, to discuss joint efforts to enhance Palestinian security. Obama did the same, seven years ago, not congratulating the Israeli election winner (Netanyahu), and snubbed the Israeli delegation on their visit, leaving them to sit alone without food or photographs.

According to the CNN expert on Antisemitism, the lefts’ dismissal of Israel’s leaders is because European Jews are not Jews at all, but Russians with no connection to the land. To my thinking claims like this against a group’s identity are horribly hurtful — CNN’s expert was claiming, essentially, that the jews were lying about everything since the beginning. If Jews are not from Israel, why have we prayed in that direction for return, and in the language of that land. If we did not build the old synagogs, when did we displace the builders and take over their language and culture? Attacks on Jewish identity are more serious, in my mind, than any march for Robert E. Lee. (I’ve written in favor of the peace hammered out between Grant and Lee).

Perhaps even more damaging is the left’s attack on Jewish education. The New York Times ran three-page article claiming that Jewish education abuses the students by not teaching real science or history, and by enforcing religious and sexual norms that are counter to the children’s rights — rights that include LGBQT+ expression. While it is true that Jewish education is not a fan of LGBQT+, but neither is Moslem education, or Catholic, or Mormon. Education is how a culture survives. Some Catholic leaders have noted that they have a stake in this.

The left is anti Israel and anti Jewish education, yet claims to be the defenders of Jews because they can’t stand Trump.

Speaking of survival, about half of all Jews now live in Israel, a state established by the UN in 1947 in part as a response to the mass murder of Jews in Europe. Along with Europeans, about half of the Israelis today are exiles from communities wiped out by Moslem governments: from Egypt, Tunisia, Iran, Iraq, Turkey, and Yemen. If Israel becomes Islamic as Obama favored, they are likely to exile all the Jews as they did in 1968 in Jerusalem, and as the surrounding countries have done. Where would the Jews go? It’s not a problem for Obama-Biden, but it’s a survival problem for Israelis. My sense is that the left is, by far, the more antisemitic, both in terms of culture and physical safety.

Robert Buxbaum, November 7, 2022

Fauci, freedom, and the right to be wrong.

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Doctor Anthony Fauci has been giving graduate addresses at colleges around the country for the past few months, telling students about his struggles and successes in the medical research world, hammering a moral point that they should expect the unexpected and have no tolerance for “the normalization of untruth”, and for “egregious twisting and lies” as were leveled against his approach to COVID (and global warming, it seems). Untruths, racism, and lies spread by “some elected officials”, presumably his exboss. Here is his speech to the Princeton graduates, or see a brief summary of his talk st the University of Michigan.

Dr. Fauci may have the best intentions in criticizing others and deputizing students to enforce the truth.He certainly seems sure that his truth and intentions are 100% pure, but what if Fauci wasn’t quite right, or what if you thought his cure to the pandemic was less than marvelous. His truth may mot be real truth, or real truth for everyone. Beyond that, even if he were always 100% right on science, I believe that people have a fundamental right to make mistakes. “I have a right to be wrong,” as Joss Stone says (see music video). Freedom from imposed righteousness is a fundamental good. Even assuming that Fauci’s lockdowns were the height of righteousness, we have a right to take risks and to act against our own best interests, in my opinion. Consider a saint who really knows what’s right and only wants to do only what’s right. I doubt that even the saint wants a jailer to force it upon him and remove his free will. And the right of the rest of us may not want to do what’s ideal and healthy. We like ice cream even thought we know it’s fattening, and we should have the right to smoke too.

This right to our mistakes is something we deserve, even assuming that Fauci knows the truth for everyone, and that everyone has the same truth, and that all of his rules were for the best. But different people are different, and people’s preferences are different. “A sadist is a masochist who follows the golden rule,” as the saying goes, and Fauci may have been out-and-out wrong.

Humor from a time when one could tolerate hearing that their truths might not be true.

Concerning COVID, I’ve noted that, despite Fauci’s lockdowns and mask mandates, The US did worse than Sweden, and my home state of Michigan did worse than Sweden — worse in terms of deaths, and far worse economically. Michigan has the same size population as Sweden and the same climate and population density so it’s a good comparison. Florida did better than we did too, though they too didn’t close the schools or have mask mandates. Their economy did better too, and children’s education.

Was Fauci right to shut K-12 schools, or to send college students home? Maybe he was only half-right, or totally wrong and blinded by politics. The more Fauci and friends deny having political interests, the more they seem political. Many Fauci’s emails have become public, and he seems highly political, and very often wrong. He also does not take seriously the economic or mental or educational problems caused to the workers that he now blames on his critics. He also seems takes it as a given that those pushing hydroxychloroquine or surface disinfection were liars, despite scientific opinion on the other side.

Fauci’s push for masks went with his claim that surfaces were not major spreaders. I think the opposite is true, and used my blog and YouTube to push iodine as a surface sanitizer and hand wash. Most diseases are spread by surfaces, and I see no reason for COVID to be different. Iodine is known to kill COVID virus, and all virus, fungus, and bacteria. It’s far more lang-lasting than alcohol, too. Maybe I’m wrong, but maybe I’m right, and I have a right to express my science without fear of censure from Fauci’s deputies. As I see it, when an infected person coughs out-spews big droplets and small droplets. The big drops contain far more virus particles. They fall quickly and dry, ready to be picked up by someone who touches the residue. As for the smaller drops, some are certainly locked by masks, but these have fewer virus particles. Besides, the mask just becomes a new surface; you’ll touch your mask to adjust it or take it off. Unless you disinfect your hands with something strong like iodine the virus on your hands will go to your eyes or nose. Trump favored Chlorox for surfaces, and was skewered for it by Fauci and his experts. I think that was wrong, made worse by claims that he was not telling you to inject the Clorox.

On climate too, we do students a disservice by closing the discussion. It’s clear that Gore’s inconvenient truth isn’t completely true, nor are his remedies beneficial, in my opinion. To stop someone’s ability to make mistakes is to wrong him, and limit him. The same applies to many things; the fellow in power always thinks he’s right, and will always have allies to back him. When Robespierre was the enforced virtue and truth during the French Revolution, everyone agreed, but we now think he was wrong. Robespierre removed the head of France’s greatest scientist, Lavoisier. It would take another generation to grow another head like that.

In terms of interesting speeches to the graduates, As Marx said (Groucho), “I thought my razor was dull, till I heard his speech.” There here’s a speech against something.

Freedom is the right to be wrong, and stubborn, like Groucho. Now that’s a graduation speech!

Robert Buxbaum, October 28, 2022

Tests designed so that the Ivies pick preppies.

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Elite colleges strive to be selective, and they are, just not for the hard-working scholars they claim to select for. They claim to be color-blind, income-blind, and race-blind, aiming for the best: the most intelligent, most ethical, and hardest working scholar-candidates. Then, to their surprise and satisfaction, all the ivies find that the vast majority of the chosen come from the same rich families and prep-schools as 100 years ago. That happens because the selection is crooked with measures tilted to the rich, Protestant, and preppy.

Through most of the 1900s, most of the ivies had a Jewish quota, enforced formally or informally. They also did their best to discourage middle class, black, and Catholic students in the interest of maintaining the proper student mix. Under Woodrow Wilson, Princeton went further and admitted not one black student. When quotas became illegal, schools began to rely on athletics and tests, with blatant cheating as revealed by the “Varsity Blues” sting operation. In that sting, a dozen or more athletic coaches and high-school administrators were caught taking SAT tests for their richer, connected students, and/or making up phony athletic achievements. The Ivies claimed shock after the cheating was revealed, but it is beyond belief that no one had noticed that these top brains and athletes were neither.

Many top athletes are diagnosed as asthmatic. Some actually are. With the right doctor, you can get an advantage

Another version of this is that richer kids can get extra time to do SAT and ACT tests. The extra time doesn’t show up on the SAT or ACT score, you need a doctor to certify that you are dyslectic or have severe ADHD. Most boys are diagnosed with ADHD these days, itself something of a scam, but most boys don’t get extra test time. You need the right doctor and the right documentation, plus enough money and connections to get the test given by certified test-giver in your own private room. It used to be that the SAT and ACT would report the extra time, but this changed in 2004. Now the extra time, and the disease is not documented, just the higher score. There have been complaints, but the scam goes on. Similar to this, top Olympic athletes can be diagnosed with asthma, and allowed to use performance enhancing, anti-asthma steroids. Again complaints, but no change.

Ivy League schools also tilt to the right families by requiring signs of the right sort of leadership as evaluated by an interview and an essay (see my post on John Kennedy’s essay). You score high on leadership if you helped your relative run for governor. By contrast, if you organized a ping-pong or basketball tournament at your Catholic or Jewish school, you’re the wrong sort of leader. Eagle Scout is sort-of the right sort, and speaking against climate change on TV is. Greta Thernberg and Chelsea Clinton are climate leaders; you, probably are not.

The Ivys explicitly state that they choose for athleticism, but not all sports are equal. All the Ivies claim to need a good women’s lacrosse team, a good crew team, and some good high-divers. Are these sports unavailable at your high-school? What a shame, you’re not a real athlete. You can still try to get in based on extreme leadership and academics.

The Princeton alumni of 1993-1994 were primarily white, rich and preppy. Favoring their children helps insure that the class of 2024 is that way too.

There is no real reason that Harvard needs a top crew team, or needs to excel at women’s lacrosse or high-diving. Sport was not an admission criteria in the 1800s. It was added in the 1900s to avoid admitting Catholics, Jews, and Asians who tended to score well but could not compete on the selected sports. The president of Harvard, Abbot Lowell wrote, “Somehow or other the enrollment of the Jewish students must be limited”. The method he chose, and that all the Ivies came to use, included these tests of leadership and sport, plus a preference for legacies. The children and grand-children of alumni are given significant preferential selection at all the ivies. At Harvard, the acceptance rate for legacy students is about 33%, compared with an overall acceptance rate of under 6%. Since legacies are mostly white, rich, protestant, and preppy, the next generation is guaranteed to be the same.

The Ivies’ methods have been challenged many times over the years. Quotas were found to be illegal as early as 1964. Since then there have been claims of effective quotas, a cause that was pushed under the rug until Donal Trump took it up. Most recently, Harvard, Princeton, and UNC were sued by Asians. One of these, from a poor background scored at the top of his class with a 4.4 GPA and had near-perfect SAT scores, but was rejected for no obvious reason beyond race. The Supreme Court is expected to hear the case in 2023. Ahead of this decision, all eight Ivies have decided to dispense with testing for at least for now. The ivies claim that, by making tests optional, they will avoid locking out students who are great (though somewhat illiterate and innumerate). The real purpose seems to be to lock out pushy Asians who might sue them or be so bright they make the legacies feel dumb.

None of the above would matter if the Ivies were not so wonderful, at least the better ones are. I went to Princeton grad school, see photos. It was great despite its waspy leanings. If you can go there, or to Harvard, Yale, Cornell or Penn, go. My feeling for Brown and Columbia are rather the opposite: they’ve gone to the extreme and voted for BDS, see the text here for Brown’s version. Not only did they vote to boycott Israelis and Israeli produce, the “B” of BDS, the’ve also committed to suppress Zionists everywhere. That’s Jews who support Israel. Several, non ivy schools, have committed to the same. In their view, for open debate to flourish anywhere, proud Jews must be excluded. These are no longer colleges, but Klavens.

Robert Buxbaum, October 20, 2022.

John Kennedy’s Nazi spy lover

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Photo and biographical background from Julian Wiles

Kennedy was a well-liked president with several character flaws. The most famous were his sexual dalliances. One these was with a Nazi spy, Inga Marie Arvad, “Inga Binga”. He continued with her, on and off, from his days in Naval Intelligence through his election to congress in 1946 despite being informed of her background by the navy and the FBI. When they began their relationship, Inga Marie was beautiful, 28 and married. That didn’t seem to matter, as she was beautiful, the ex-Miss Denmark, charming and instantly in love with Kennedy. She was also a close friend of Hitler, Goring, and Göebbels, and in the employ of both The Washington Times-Herald and of Axel Wenner-Gren, a suspected Nazi spy master who owned the largest private yacht in the world. It was suspected that the fuel Wenner-Gren bought for his yacht was used to refuel German U-boats in the area.

Before becoming involved with Kennedy, Ms Arvand had married Kamak Abdel Nabi, an Egyptian diplomat, and then Paul Fejos, a Hungarian film-maker. She traveled the world with Fejos, financed by Wenner-Gren, meeting, greeting, and film-making. Still married, she left Fejos in 1936 to move to the US and study journalism at Columbia University. Getting a job at the Washington Times-herald, she wrote light hearted articles based on interviews with the movers and shakers of DC, supported by $5000 checks from her friend, Wenner-Gren.

The affair with Kennedy began in the fall of 1941. Kennedy was working at the Office of Naval Intelligence, a post he’d gotten with influence from his ambassador father, “Big Joe Kennedy”. Joe was an opponent of going to war. Ms. Arvand heartily agreed. She met Jack Kennedy through his sister, Kathleen, “Kick”.

The office of Naval Intelligence had rules against adulterous relationships. Kennedy ignored them. In this case it was particularly problematic as Inga was married, Protestant, and an associate of Hitler. The navy told Kennedy to stay away, and transferred him to Charlestown with orders to stay there, “not to venture more than 50 miles”. Ms Arvad visited him there often under an assumed name, Barbara White. They stayed together, took in movies, plays, and golf. The FBI watched as Arvad was thought to be a spy. Kennedy was again told to stay clear; he did not. Eventually, Hoover intervened and got Kennedy transferred to the South Pacific despite his bad back and other health problems. Inga broke off with Kennedy though he continued to write love letters. She ignored them. Perhaps she thought Kennedy was no longer interesting, even a liability. She was trying to get a job with US overseas intelligence, the forerunner of the CIA.

Inga with husband, and two children. Note that the older, Ronald, looks like J. Kennedy. Photo from Geoffrey Gray.

When Inga didn’t get the job, she moved to Los Angeles where she continued in journalism, working for Harpers Bazar, interviewing the movers and shakers in LA and New York, generally pushing for peace. In January, 1944, she started writing to Kennedy again. He was a hero with political ambitions. She reunited with Kennedy in LA, for a private interview, published, about the sinking of his PT boat. They continued dating well into 1946, after Kennedy was elected to congress. Inga got pregnant from someone (Kennedy?) and left to marry an actor she’d been dating, Tim McCoy. Some months later, Inga gave birth to a boy who looks a lot more like Kennedy than like her husband, see photo.

While Inga no longer contacted JFK, nor JFK her, it seems that Inga was a major factor influencing Kennedy to go into politics — where he could make the world more peaceful. Inga died of Colin cancer in 1973. She only revealed her part of the affair to her eldest son, the Kennedy look-alike, near the end of her life.

The FBI’s knowledge of this story this emerged from the private files of J. Edgar Hoover, recently unsealed, reported by investigative writer, Geoffrey Gray. He speculates that Hoover used his knowledge of Kennedy’s affairs to keep from having to retire, though well past retirement age. Hover was eventually removed by Nixon, and FBI got back at Nixon by leaking as much negative as they could to the press, and more-recently helping the Democrats bug the Trump campaign, then helping spread Russian collusion documents. Also, according to the BBC they were behind the plot to kidnap MI governor Whitmer — a crime they immediately “solved”. I’m not convinced that the FBI, isn’t more of a danger than a protection. See a previous essay, “who will protect us from our protectors?”

Regarding John Kennedy, I’m less-bothered by his sexual dalliances, than by his tendency to suddenly reverse himself. Kennedy called for an attack on Cuba, then reversed while the attack was in progress, dooming the attackers. He reversed again in South Vietnam, first first supporting the government then overthrowing it, and on civil rights. Vigorous persistence, even in the face of criticism is a good trait in a president, something I liked about LBJ, Nixon, Clinton, and Reagan.

Robert Buxbaum, October 14, 2022.

How to tell who is productive if work is done in groups

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It is a particular skill of management to hog the glory and cast the blame; if a project succeeds, executives will make it understood that the groups’ success was based on their leadership (and their ability to get everyone to work hard for low pay). If the project fails, a executive will cast blame typically on those who spotted the problem some months early. These are the people most likely to blame the executive, so the executive discredits them first.

This being the dynamic of executive oversight, it becomes difficult to look over the work of a group and tell who is doing good and who is coasting. If someone’s got to be fired in the middle of a project, or after, who do you fire? My first thought is that, following a failure, you fire the manager and the guy at the top who drew the top salary. That’s what winning sports teams do. It seems to promote “rebuilding” it’s a warning to those who follow. After the top people are gone, you might get an honest appraisal of what went wrong and what to do next.

A related problem, if you’re looking to hire is who to pick or promote from within. In the revolutionary army, they allowed the conscripts to pick some of their commanders, and promoted others based on success. This may not be entirely fair, as there are many causes to success and failure, but it seemed to work better than the British system, where you picked by birth or education. Here’s a lovely song about the value of university education in a modern major general.

A form of this feedback about who knows what he’d doing and who does not, is to look at who is listened to by colleagues. When someone speaks, do people who know listen. It’s a method I’ve used to try to guess who knew things in a field outside my own. Bull-shitters tend to be ignored when they speak. The major general above is never listened to.

In basketball or hockey, the equivalent method is to see who the other players pass to the most, and who steals the most from the other side. It does not take much watching to get a general sense, but statistics help. With statistics, one can set up a hierarchical system based on who listens to whom, or who passes to whom with a logistic equation as used for chess and dating sites. A lower-paid person at the center-top is a gem who you might consider promoting.

In terms of overall group management, it was the opinion of W Edwards Deming, the name-sake of the Deming prize for quality, that overall group success was typically caused by luck or by some non-human cause. Thus that any manager would be as good as any other. Deming had a lovely experiment to show why this is likely the case– see it here. If one company or team did better year after year, it was common that they were in the right territory, or at the right time. As an example, the person who succeeded selling big computers in New York in the 1960s was not necessarily a good salesman or manager. Anyone could have managed that success. To the extent that this is true, you should not fire people readily, but neither worry that your highest paid manager or salesman is irreplaceable.

Robert Buxbaum, October 9, 2022

A new, higher efficiency propeller

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Elytron biplane, perhaps an inspiration.

Sharrow Marine introduced a new ship propeller design two years ago, at the Miami International Boat show. Unlike traditional propellers, there are no ends on the blades. Instead, each blade is a connecting ribbon with the outer edge behaving like a connecting winglet. The blade pairs provide low-speed lift-efficiency gains, as seen on a biplane, while the winglets provide high speed gains. The efficiency gain is 9-30% over a wide range of speeds, as shown below, a tremendous improvement. I suspect that this design will become standard over the next 10-20 years, as winglets have become standard on airplanes today.

A Sharrow propeller, MX-1

The high speed efficiency advantage of the closed ends of the blades, and of the curved up winglets on modern airplanes is based on avoiding losses from air (or water) going around the end from the high pressure bottom to the low-pressure top. Between the biplane advantage and the wingtip advantage, Sharrow propellers provide improved miles per gallon at every speed except the highest, 32+ mph, plus a drastic decrease in vibration and noise, see photo.

The propeller design was developed with paid research at the University of Michigan. It was clearly innovative and granted design patent protection in most of the developed world. To the extent that the patents are respected and protected by law, Sharrow should be able to recoup the cost of their research and development. They should make a profit too. As an inventor myself, I believe they deserve to recoup their costs and make a profit. Not all inventions lead to a great product. Besides, I don’t think they charge too much. The current price is $2000-$5000 per propeller for standard sizes, a price that seems reasonable, based on the price of a boat and the advantage of more speed, more range, plus less fuel use and less vibration. This year Sharrow formed an agreement with Yamaha to manufacture the propellers under license, so supply should not be an issue.

Vastly less turbulence follows the Sharrow propeller.

China tends to copy our best products, and often steals the technology to make them, employing engineers and academics as spys. Obama/Biden have typically allowed China to benefit for the sales of copies and the theft of intellectual property, allowing the import of fakes to the US with little or no interference. Would you like a fake Rolex or Fendi, you can buy on-line from China. Would you like fake Disney, ditto. So far, I have not seen Chinese copies of the Sharrow in the US, but I expect to see them soon. Perhaps Biden’s Justice Department will do something this time, but I doubt it. By our justice department turning a blind eye to copies, they rob our innovators, and rob American workers. His protectionism is one thing I liked about Donald Trump.

The Sharrow Propeller gives improved mpg values at every speed except the very highest.

Robert Buxbaum, September 30, 2022

A great modern artist, Duchamp becomes a great modern chess player, and returns to art.

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I’d written previously about Marcel Duchamp’s early work as a founder of the Dada school of modern art, a school that aims to say nothing about anything except about itself. Duchamp hung a urinal as art and called it “fountain.” It was comic, insulting, and engaging — an inspiration for many modern arts to follow , and much bad modern art, too — the collections of string and found objects and paintings of squares or squiggles. But the story of Duchamp is interesting. In 1925, M. Duchamp gave up on art, at least this type of art and became a chess player. As with art, he was very good at it, and became the French chess champion. Now that’s an unexpected turn.

What sort of chess did Marcel Duchamp play? Modern. Very modern. While tradition chess had focussed on the center. He developed at the sides, a strategy that was called an “Indian attack”, named (I assume) after American Indians attacking a stage-coach. Instead of attacking directly, the popular image of an Indian attack is attack from the sides, or behind trees. In chess, it involves typically a “fianchettoed bishop.” Other modern chess players of the time attacked from the side too (Réti, Alekhine) but they generally worked form one side or the other with some central presence. Duchamp worked from both, often with no center.

Position after white’s 13th move

Here is a dramatic example, a position from a game with an American great, GM George Koltanowski. It’s 13 moves in, with Duchamp, is black, generally considered the weaker side. He has fianchettoed both of his bishops, and given up the center to Koltanowski. It’s Duchamp’s turn to move/ He will win in three moves.

Notice that Koltanowsi’s bishops point outward, as a cowboys guns might point, or as from a British fighting square. Meanwhile, Duchamp’s bishops point inward, with his queen -bishop almost directly at the white king. The game proceeded as follows. 13…, Nxd5 14.Nxd7, Nxf4 15.Nxf8, Bd4, 0-1..

The full game, seen here,. It might prove instructive if you want to explore in Duchamp’s footsteps. While I play traditionally, I sometimes fianchetto, and do not find it racist that such side-attacks are called “Indian attacks.” Perhaps that’s because I’m old and used to such things, or because they very often work.

Please Touch. M. Duchamp 1947
Self-portrait, M. Duchamp, 1957 (torn paper on black velvet).

As M. Duchamp’s chess skills waned, he returned to the art world, going in the opposite direction of Dali. Duchamp’s last works are small, and simple. They are still arresting but more dream-like. Dali’s works grew bigger and busier as he got older.

That Duchamp could be both a great artist and a great chess-player suggests there is such a thing as general intelligence. It’s a touchy subject, I’ve pondered on here as intelligence appears to be inheritable.

Robert Buxbaum, September 23, 2022.

Eliquis, over-prescribed but better than Coumadin.

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Eliquis (apixaban) is blood thinner shown to prevent stroke with fewer side effects than Warfarin (Coumadin). Aspirin does the same, but not as effectively for people over 75. My problem with eliquis is that it’s over-prescribed. The studies favoring it over aspirin found benefits for those over 75, and for those with A-Fib. And even in this cohort the advantage over aspirin is small or non-existent because eliquis has far more serious side effects; hemorrhage, or internal bleeding.

Statistically, the AVERROES study (Apixaban Versus Acetylsalicylic Acid to Prevent Stroke in AF Patients Who Have Failed or Are Unsuitable for Vitamin K Antagonist Treatment) found that apixaban is substantially better than aspirin at preventing stroke in atrial fibrillation patients, but worse at preventing heart attack.

Taking 50 mg of Eliquis twice a day, reduces the risk of stroke in people with A-Fib by more than 50% and reduces the rate of heart attack by about 15%. By comparison, taking 1/2 tablet of aspirin, 178 mg, reduces the risk of stroke by 17% and of heart attack by 42%. The benefits were higher in the elderly, those over 75, and non existent in those with A-Fib under 75, see here, and figure. Despite this, doctors prescribe Eliquis over aspirin, even to those without A-Fib and those under 75. I suspect the reason is advertising by the drug companies, as I’ve claimed earlier with Atenolol.

The major deadly side-effect is hemorrhage, brain hemorrhage and GI (stomach) hemorrhage. Here apixaban is far worse than with aspirin (but better than Warfarin). The net result is that in the AVERROES random-double blind study there was no difference in all-cause mortality between apixaban and aspirin for those with A-fib who were under 75, see here. Or here.

To reduce your chance of GI hemorrhage with Eliquis, it is a very good idea to take a stomach proton pump drug like Pantoprazole. If you have A-Fib, the combination of Eliquis and pantoprazole seems better than aspirin alone, even for those under 75. If you have no A-Fib and are under 75, I see no benefit to Eliquis, especially if you find you have headaches, stomach aches, back pain, or other signs of internal bleeding, you might switch to aspirin or choose a reduced dose.

A Japanese study found that half the normal dose of Eliquis, was approximately as effective as the full dose, 50 mg twice a day. I was prescribed Eliquis, full dose twice a day, but I’m under 70 and I have no A-Fib since my ablation.

Life expectancy has dropped in the US to undeveloped world levels. Biden blames COVID and racism. I think it’s too much drugs, and too few opportunities.

I’m struck by the fact that US life expectancy is uncommonly low, lower than in most developed countries. Lower too than in many semi-developed countries, and our life expectancy is decreasing while other countries are not seeing the same. It dropped by about 3 years over the last 2 years as shown. I wonder why the US has suffered more than other countries, and suspect we are over-prescribed. Too much of a good thing, typically isn’t good.

Robert Buxbaum, September 16, 2022. As a side issue, low dose aspirin may forestall Alzheimers and other dementias. See current article here. Also another study here.