Tag Archives: dementia

We’re depressed, allergic, overweight, alone, and demented. What causes what?

Among the wonders of the western world is how many people are allergic to nuts compared to a few decades ago, and to gluten, and to a host of other things that hardly anyone was allergic to 50 years ago. Perhaps it’s a change in perception, but it doesn’t seem that way.

When I was in public school in NY, back in the 1960s, there was a subsidized lunch program serving, every day, peanut butter sandwiches. Peanut butter is nearly totally fat. It was ladled each day, from a giant tub, provided by the USDA, and slathered on USDA bread along with jelly from some other vat. The smell filled the lunch area, and the fats and sugars filled our stomaches. No one seemed bothered by the nuts, and no one showed obvious signs of passing out. And despite the ill diet, we were less obeease than today. Even today, in poor countries, thy still serve massive peanut butter dishes, or bread covered in lard, and these countries show fewer allergy problems, and less obesity in general.

Perhaps it is the lack of exposure to peanuts in the US that caused the allergy (sounds almost plausible), and maybe it’s the dietetic food that causes obesity, and the glut of non-gluten that causes gluten allergies. These connections may be false, but If true, it would suggest we’re in for many more problems.

Moving to depression and dementia. We’re seeing more and more of both, and at earlier ages. In our era, virtually everyone over 80 shows signs of clinical dementia, often Alzheimer’s dementia, but the rates are rising, especially in those 55-70, and it seems most every adult is depressed. I don’t know why, though lots of people on the internet have speculative explanations. There are also cures, and perhaps some work. The research behind at least one of the best hopes for an Alzheimers cure was shown to be falsified, just made up. Not that funding was stopped quite, highlighting another problem that is becoming more common: people in trust positions no longer behave in a trustworthy way. Nor are they punished for lying. Strange to add that an anti-obesity drug, Metformin, seems to actually work at weight loss, and helps against Alzheimers dementia. Then again, from other research, it seems that obesity protects from dementia.

Some of the problem seems to be societal, a lack of friendship and companionship. I could imagine that isolation leads to dementia, depression, and weight gain. Another thought, pushed by RFK Jr., is that new drugs and vaccines are responsible for allergies and ADHD, along with changes in diet. It’s possible. At least some comes from early diagnosis, and a change in the definition of dementia. Perhaps that’s the reason for the significant difference state to state. Yesterday’s curmudgeon is redefined as depressed, and drugged (more in some states than others), and becomes isolated (again more in some communities). The disoriented, lonely patient is then given anti anxiety drugs and classified as a dementia patient. It happens in some cases, but there seems to be a rise in real dementia too: the sort of stumbling and blankness that reflects general brain deterioration. As for ADHD, I’m still not convinced this is a new real disease; it could be that’s how boys always behaved.

Would we be less depressed or demented or less autistic with different vaccinations, or different foods, or with more human interaction? Would people be less isolated if they were less depressed or autistic? RFK’s family now claims that RFK Jr is demented himself for even asking these questions. My guess, totally unsupported is that the rise in allergies, dementia, obesity, and depression are related somehow, but I’m not convinced that RFK Jr. has picked out the right connection. What causes what? Perhaps someone can use statistics, or biology experiments to help untangle this stuff. It seems horribly important to the majority of Americans.

Robert Buxbaum, Sept 10, 2024. There was a. bit of a joke in the last comments: my daughter got a degree in epidemiology, and is employed in part to answer just the sort of questions I’ve posed.

Fat people live longer, show less dementia

Life expectancy is hardly affected by weight in the normal - overweight- obese range. BMI 30-34.9 = obese.

Life expectancy is hardly affected by weight in the normal – overweight – obese range. BMI 30-34.9 = obese.

Lets imagine you are a 5’10” man and you weigh 140 lbs. In that case, you have a BMI of 20, and you probably think you’re pretty healthy, or perhaps you think you’re a bit overweight. Our institutes of health will say that you are an “average-wight” or “normal-weight” American, and then claim that the average-weight American is overweight. What they don’t tell you, is that low weight, and so-called average weight people in the US live shorter lives. Other things being equal, the morbidity (chance of death) for a thin American, BMI 18.5 is nearly triple that of someone who’s obese, BMI 32. The morbidity of the normal-weight American is better, but is still nearly double that of the obese fellow whose BMI is 32.

Our NIH has created a crisis of overweight Americans, that is not based on health. They work hard to solve this obesity crisis by telling people to jog to work, and by creating ever-more complicated food pyramids. Those who listen live shorter lives. A prime example is Jim Fixx, author of several running books including “The complete Book of Running.” He was 52 when he died of a heart attack while running. Similar to this is the diet-expert, Adelle Davis, author of “Let’s eat right to keep fit”. She died at 70 of cancer — somewhat younger than the average American woman. She attributed her cancer to having eaten junk food as a youth. I would attribute it to being thin. Not only do thin people live shorter lives, but their chances of recovering from cancer, or living with it, seem to improve if you start with some fat.

The same patter exists where age-related dementia is concerned. If you divide the population into quartiles of weight, the heaviest has the least likelihood of dementia, the second heaviest has the second-least, the third has the third-least, and the lightest Americans have the highest likelihood of dementia. Here are two studies to that effect, “Association between late-life body mass index and dementia”, The Kame Project, Neurology. 2009 May 19; 72(20): 1741–1746. And “BMI and risk of dementia in two million people over two decades: a retrospective cohort study” The Lancet, Volume 3, No. 6, p431–436, June 2015.

Morbidity and weight, uncorrected data, and corrected by removing the demented.

Morbidity and weight, uncorrected data, and corrected by removing the demented. The likelihood of dementia decreases with weight.

Now you may think that there is a confounding, cause and effect here: that crazy old people don’t live as long. You’d be right there, crazy people don’t live as long. Still, if you correct the BMI-mortality data to remove those with dementia, you still find that in terms of life-span, for men and women, it pays to be overweight or obese but not morbidly so. The study concludes as follows: “Weight loss was related to a higher mortality risk (HR = 1.5; 95% CI: 1.2,1.9) but this association was attenuated when persons with short follow-up or persons with dementia were excluded.” As advice to those who are planning a weight loss program, you might go crazy and reduce your life-span a lot, but if you don’t go crazy, you’re only reducing your life-span a little.

In terms of health food, I’ve noticed that many non-health foods, like alcohol and chocolate are associated with longevity and mental health. And while low-impact exercise helps increase life-span, that exercise is only minimally associated with weight loss. Mostly weight loss involves changing the amount you eat and changing your clothes choices to maximize radiant heat loss.

Dr. Robert E. Buxbaum, October 26, 2017. A joke: Last week I was mugged by a vegan. You may ask how I know it was a vegan. He told be before running off with my wallet.