Tag Archives: Sweden

Vaccines barely worked, lockdowns seem to have made it worse.

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The first 15 months of the pandemic were grim periods of lockdown, except in Sweden where the health minister declared that lockdowns would not do anything except delay the inevitable. They chose to protect only the most vulnerable, and kept everything else open. By May, 2021, it looked like that was a mistake. Sweden had a seen a sickness and death rate that was fairly average for the world, but high compared to more locked down nordic countries, like Norway, Finland, and Germany. And now vaccines were here that were supposed to be 100% effective, both at stopping the sickness and the spread. We were at the end, opening up, and Sweden had blundered. They had ‘ignored the science,’ as Fauci put it.

Excess mortality January 26 2020 to March 1, 2023, from Our World in Data. I focus on excess deaths here, rather than COVID specifically, because death is a metric that is hard to fudge.

Unfortunately, it quickly became clear that the vaccines were far less than 100% effective. The current estimate is that 2 shots are 24% effective at preventing the disease and 0% effective at preventing the spread. This is a problem in much of medical science these days: successful results tend to be irreproducible, I discuss the reason here. The disease had evolved, and somehow the experiments had not noticed. What’s more they had side-effects (all drugs do). People were dying at a faster rate than before in the US, and in many European countries (see graph below). There was no flattening of the curve suggesting that the vaccine didn’t work. By last year, I had noticed that US COVID deaths did not decrease with the advent of vaccines. Strangely, deaths did not increase as fast in Sweden. By 2022, Sweden was doing better than its lock-down peers. As of today, it’s doing much better. So, what have we learned?

The results of the 6 month Pfizer trial already suggested there might be a problem -that perhaps the vaccine did more harm than good. The above were the results in the Biologics Licence Application (BLA) report (page 23), submitted to the Food and Drug Administration (FDA) to apply for vaccine approval, November, 2021. The vaccine decreased COVID but increased other cause death even more. Suspicious.

The fact that the death rate did generally not go down when a majority were vaccinated and the most vulnerable were already dead suggests that vaccination does not help much. That excess death increased in some countries (Norway, Finland, Germany) suggests that either the side-effects of the vaccine are worse than the disease itself or that some other aspect of the treatment (lockdowns?) were worse than the disease. The vaccine still may be shown to have helped, but it doesn’t look like it helped much. The fact that lock-down countries are doing worse than Sweden suggests that lockdowns actually hurt. This is significant. One thing to learn is that you have a right to not trust medical science: you have a right to be wrong. Mr Spock never trusted Bones’s medicine. You have a particularly strong right to doubt when you have evidence as strong as the map below (excess deaths in Europe as it stood in December 2021). Already Sweden was doing well and the experts were looking very wrong.

A map of excess deaths in Europe as of December 2021. Already many countries had passed Sweden. Eastern and Southern Europe were particularly hard hit.

I can now speculate on the mechanism; why might lockdowns hurt or kill? I suggested it’s loneliness. Perhaps it’s inaction, or mental distress. People would rather get an electric shock than sit a think without doing anything. It might be that lockdowns prevented other medical treatment. Whatever the mechanism, you’d think that our government would have acknowledged, by early 2022, that lockdowns were not working. Instead virtually every state continued lockdowns through a good chunk of 2022 with school closures, limited seating, etc.

I suspect that “long COVID” may be a form of lock-down depression plus associated noxious behaviors: increased drug and alcohol use, lack of exercise, and avoiding treatment for health problems. I suggested iodine hand wash (and gargle) to stop the disease spread (I imagine it’s on surfaces), and still think it’s a good idea. Iodine is cheap and it definitely kills all germs. Other anti-isolation nostrums include exercise, lithium, aspirin, letters, and hydroxycholoroquine. There was reasonable statistical evidence for several of these things helping, though Fauci denied it. Perhaps they only helped via ‘the placebo effect’. But placebo cures are real, especially for mental problems.

Robert Buxbaum, March 30, 2023. As an add-on (April 2, 2013), I’d like to show the decline in life-expectancy in the US compared to other countries. Isolation is a killer. A lot of the blame goes to Fauci for continuing to push socially isolating solutions as “the science”, while blasting any who say otherwise. We’ve lost 3 years of life-span in 3 years — preventably avoided — when other countries have lost zero or one. There could be no greater inditement of the health management.

This is from the Financial Times. The US is doing worst of all in terms of lives lost to the pandemic and it continues. Isolating people is torture. We then blame them for feeling distrust. I blame Biden and Fauci.

COVID-19 in Sweden vs the US; different approaches, near identical outcomes.

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Today, Michigan and several other, Democrat-run states are in fairly broad COVID lockdown. The justification for this is that it is “THE science”, as if this were the only possible behavior if you believe the disease is deadly and contagious. The other fellows, the governors of Republican-run states are framed as deniers of the science. Strangely enough, although this disease is most -definitely contagious and deadly, killing 209,000 Americans so far, about 0.064% of the US this year, it is far from clear that a broad lockdown is the only way to stop the disease. Sweden avoided a general lockdown, leaving its schools and restaurants open, and has seen the disease follow an almost destructive path to that of the US, with a death rate that is currently slightly lower than ours. See the excess death plot below. Sweden seems to have avoided a second, summer spike.

Mortality is Sweden vs the US; Ignore the last 2-3 weeks, it takes time for this data to be compiled

It’s bad enough for “THE SCIENCE” when you see the anti-science, no-lockdown solution provide the same result, or close. Earlier in the summer I noted that Sweden and Michigan had near the same outcome, with Sweden slightly better. It’s now the case that Sweden is doing better than the US, and much better than the D-lead lockdown states. The highest six death rate states are all D-lead, lockdown states, NY, NJ, Mass, Conn, LA, and RI, and rates are double the US average in New York and New Jersey. Perhaps the solution is a general opening, like in Sweden, but before we rush to this, it’s probably worthwhile to do some re-thinking.

Deaths per week, under 18. Any excess deaths caused by COVID-19 are invisible here, lost in the scatter.

One thing that Swedes seem to have appreciated that the US experts didn’t is that the disease hardly affects those the under 18, and that’s basically the entire K-12 student body. Sweden therefore left their K-12 schools open, while we closed ours in the US beginning in early April. At right I’ve plotted the US deaths per week for under 18 for the last three years, that is from before COVID till now. There is no evidence of excess COVID-19 deaths for this group. If anything anything, the under 18 death death rate is lower after COVID than before. This resistance of this group helps explain part of why the Swedish approach didn’t cause increased deaths. Kids in Sweden got the disease, but didn’t die of it, and likely infected their parents. The Swedes didn’t bother trying to protect everyone, but only the most vulnerable, the old people. Sweden was not completely successful at this, but we were perhaps worse, despite the general lockdown.

The excess deaths US for the 65+ bracket plotted by week of the year for 2020 (blue), 2019 (grey) and 2018 (yellow). Nearly 200,000 of the excess deaths of 2020 — the vast majority — are in this age bracket.

But what about the middle-age people that the kids would have infected, the parents and teachers. For middle age people, those in the 18-65 range, it seems to make a difference how physically fit you are, and the Swedes tend to be fit. Obesity is a big co-morbidity for this disease, and Americans tend to be obese, with things getting worse during the lockdown. Swedes also wash their hands more than we do (or so is their reputation) and they go out in the sun. There is evidence that the sun helps, and vitamin D too. A stark way of seeing how much fitness helps, for even those over 18 is to consider that, of the 1.3 million men and women of the US military, there have been only 7 COVID deaths. That is a rate 1/100 of the national average for a population that is entirely over 18. This is not to say that the death rate is quite 5 per million, (7/ 1.3 million = 5 per million), but it’s probably below 50 per million. That is to say, at least 10% of the military was likely infected.

I’m inclined to agree with Dr. Fauchi that we are not yet at herd immunity, or even close, even in states like Michigan where death rates have leveled out. Only 20% of the state shows antibodies and real herd immunity would require 75% or so. Further supporting this, our death rates are 1/2 that of New Jersey. If we were at herd immunity, that could not have happened. It is possible though that we have a sort of pseudo herd immunity, where many people in the MI population have some level of T-cell immunity. T-cells do a good job eating disease (here’s a video) but they get overwhelmed when we are exposed to more than a low dose of virus. This dose-response is common in respiratory diseases, and Dr. Fauchi has related it to T-cell immunity, though he does not speak in these directions often.

Michigan death rates to September 2020 The disease seems to be over, though only about 20% of the state shows antibodies.

T-cells can cause someone to be immune to a few viral hits, but not immune to higher doses. Assuming that’s what’s going on in MI and MA, and NJ, I’m inclined to suggest we can open up these states a bit, according to the Swedish model. That is make careful efforts to clean public transport, and encourage hand washing and surface cleaning. That we prohibit large gatherings, and we take care isolate those over 65 and protect old age homes. In the US, virtually all the deaths were of people over 65, and about half were people over 85, with men being particularly vulnerable. A heterogeneous opening of this sort has been recommended by scientists as early as March.

There are three major problems with lockdowns that keep us from all virus particles. These lockdowns kill the economy, they leave us with lousy education, and they likely leave us as at-risk for the disease later on, when the lockdown is lifted. Instead a heterogeneous opening leaves the economy running and exposes us to some small exposure, at a level that our typical level of T-cell immunity may be able to handle. Over time we expect our T-cell immunity will rise and we’ll be able to take off our masks entirely. It’s a nice route to a cure that does not require a vaccine.

The above approach requires us to trust that people will do the right thing, and requires us to accept that each may do it in his/her own way. Some may not wear the mask all the time, but may chose exercising, or staying in the sun and taking vitamin D. Some may keep to masks, or focus on hand washing. Some may try unapproved drugs, like hydroxychloroquine. We will have to be able to accept that, and our experts will have to be able to step back from running everything. In China and Russia, the experts tried run every aspect of farm production, using only science methods. The result was famine. A similar thing happened in Ireland and got a potato famine. It’s good to have expert advice, but as far as making the actual decision in each location, I put a lot of weight on the choices of those who will bear the consequences.

Robert Buxbaum September 30, 2020. As a summary, I’m for opening schools, opening most states, with masks, and hand-sanitizer, at lower occupancy ( ~50%), limiting large gatherings, going to zoom as much as possible, and isolating the aged particularly the old age homes. I also recommend vitamin D and iodine hand sanitizer.

Sweden v Michigan: different approaches, same outcome.

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Sweden has scientists; Michigan has scientists. Sweden’s scientists said to trust people to social distance and let the COVID-19 disease run its course. It was a highly controversial take, but Sweden didn’t close the schools, didn’t enforce masks, and let people social distance as they would. Michigan’s scientists said to wear masks and close everything, and the governor enforced just that. She closed the schools, the restaurants, the golf courses, and even the parks for a while. In Michigan you can not attend a baseball game, and you can be fined for not wearing a mask in public. The net result: Michigan and Sweden had almost the same death totals and rates, as the graphs below show. As of July 28, 2020: Sweden had 5,702 dead of COVID-19, Michigan had 6,402. That’s 13 more dead for a population that’s 20% smaller.

Sweden’s deaths pre day. There are 5,702 COVID dead since the start, out of a population of 10.63 million. There are 79,494 confirmed COVID cases, but likely a lot more infected.

Sweden and Michigan are equally industrial, with populations in a few dense cities and a rural back-country. Both banned large-scale use of hydroxy-chloroquine. Given the large difference in social distance laws, you’d expect a vastly different death rate, with Michigan’s, presumably lower, but there is hardly any difference at all, and it’s worthwhile to consider what we might learn from this.

Michigan’s deaths pre day. There are 6,426 COVID dead since the start, out of a population of 9.99 million. There are 88,025 confirmed COVID cases, but likely a lot more infected.

What I learn from this is not that social distance is unimportant, and not that hand washing and masks don’t work, but rather it seems to me that people are more likely to social distance if they themselves are in control of the rules. This is something I also notice comparing freezer economies to communist or controlled ones: people work harder when they have more of a say in what they do. Some call this self -exploitation, but it seems to be a universal lesson.

Both Sweden and the US began the epidemic with some moderate testing of a drug called hydroxychloroquine (HCQ)and both mostly stopped in April when the drug became a political football. President Trump recommended it based on studies in France and China, but the response was many publications showing the didn’t work and was even deadly. Virtually ever western country cut back use of the drug. Brazil’s scientists objected — see here where they claim that those studies were crooked. It seems that countries that continued to use the drug had fewer COVID deaths, see graph, but it’s hard to say. The Brazilians claim that the anti HCQ studies were politically motivated, but doctors in both Sweden and the US largely stopped prescribing the drug. This seems to have been a mistake.

US hospitals stopped using HCQ in early April almost as soon as Trump recommended it. Sweden did the same.

In July, Henry Ford hospitals published this large-scale study showing a strong benefit: for HCQ: out of 2,541 patients in six hospitals, the death rate for those treated with HCQ was 13%. For those not treated with HCQ, the death rate was more than double: 26.4%. It’s not clear that this is cause and effect. It’s suggestive, but there is room for unconscious bias in who got the drug. Similarly, last week, a Yale researcher this week used epidemiological evidence to say HCQ works. This might be proof, or not. Since epidemiology is not double-blind, there is more than common room for confounding variables. By and large the newspaper experts are unconvinced by epidemiology and say there is no real evidence of HCQ benefit. In Michigan and Sweden the politicians strongly recommend continuing their approaches, by and large avoiding HCQ. In Brazil, India and much of the mideast, HCQ is popular. The countries that use HCQ claim it works. The countries that don’t claim it does not. The countries with strict lock-down say that science shows this is what’s working. The countries without, claim they are right to go without. All claim SCIENCE to support their behaviors, and likely that’s faulty logic.

Hydroxychloroquine and COVID-19 fatality rates in different countries as of early June 2020. This isn’t enough to prove HCQ effectiveness, but it’s promising, and suggests that increased use is warranted, at least among those without heart problems.

Given my choice, I’d like to see more use of HCQ. I’m not sure it works, but I’m ,sure there’s enough evidence to put it into the top tier of testing. I’d also prefer the Sweden method, of nor enforced lockdown, or a very moderate lockdown, but I live I’m Michigan where the governor claims she knows science, and I’m willing to live within the governor’s lockdown.There is good, scientific evidence that, if you don’t you get fined or go to jail.

Robert Buxbaum, July 29, 2020. As I side issue, I think iodine hand wash is a good thing. I may be wrong, but here’s my case.