Sometimes I find I have important data that I can’t quite explain. For example, cancer rates in the US vary by more than double from county to county, but not at random. The highest rates are on the rivers, and the lowest are in the mountains and deserts. I don’t know why, but the map shows it’s so.
Cancer death rates map of the US age adjusted 2006-2010, by county. From www.statecancerprofiles.cancer.gov.
Counties shown in red on the map have cancer death rates between 210 and 393 per 100,000, more than double, on average the counties in blue. These red counties are mostly along the southern Mississippi, the Arkansas branching to its left; along the Alabama, to its right, and along the Ohio and the Tennessee rivers (these rivers straddle Kentucky). The Yukon (Alaska) shows up in bright red, while Hawaii (no major rivers) is blue; southern Alaska (mountains) is also in blue. In orange, showing less-elevated cancer death, you can make out the Delaware river between NJ and DC, the Missouri heading Northwest from the Mississippi, the Columbia, and the Colorado between the Grand Canyon and Las Vegas. For some reason, counties near the Rio Grande do not show elevated cancer death rates. nor does the Northern Mississippi and the Colorado south of Las Vegas.
Contrasting this are areas of low cancer death, 56 to 156 deaths per year per 100,000, shown in blue. These appear along the major mountain ranges: The Rockies (both in the continental US and Alaska), the Sierra Nevada, and the Appalachian range. Virtually every mountain county appears in blue. Desert areas of the west also appear as blue, low cancer regions: Arizona, New Mexico, Utah, Idaho, Colorado, south-west Texas and southern California. Exceptions to this are the oasis areas in the desert: Lake Tahoe in western Nevada and Lake Meade in southern nevada. These oases stand out in red showing high cancer-death rates in a sea of low. Despite the AIDS epidemic and better health care, the major cities appear average in terms of cancer. It seems the two effects cancel; see the cancer incidence map (below).
My first thought of an explanation was pollution: that the mountains were cleaner, and thus healthier, while industry had polluted the rivers so badly that people living there were cancer-prone. I don’t think this explanation fits, quite, since I’d expect the Yukon to be pollution free, while the Rio Grande should be among the most polluted. Also, I’d expect cities like Detroit, Cleveland, Chicago, and New York to be pollution-heavy, but they don’t show up for particularly high cancer rates. A related thought was that specific industries are at fault: oil, metals, chemicals, or coal, but this too doesn’t quite fit: Utah has coal, southern California has oil, Colorado has mining, and Cleveland was home to major Chemical production.
Another thought is poverty: that poor people live along the major rivers, while richer, healthier ones live in the mountains. The problem here is that the mountains and deserts are home to some very poor counties with low cancer rates, e.g. in Indian areas of the west and in South Florida and North Michigan. Detroit is a very poor city, with land polluted by coal, steel, and chemical manufacture — all the worst industries, you’d expect. We’re home to the famous black lagoon, and to Zug Island, a place that looks like Hades when seen from the air. The Indian reservation areas of Arizona are, if anything, poorer yet.
Cancer incidence,age adjusted, from statecancerprofiles.cancer.gov
My final thought was that people might go to the river to die, but perhaps don’t get cancer by the river. To check this explanation, I looked at the map of cancer incidence rates. While many counties repress their cancer rate data, the pattern in the remaining ones is similar to that for cancer death: the western mountain and desert counties show less than half the incidence rates of the counties along the southern Mississippi, the Arkansas, and the Ohio rivers. The incidence rates are somewhat elevated in the north-east, and lower on the Yukon, but otherwise it’s the same map as for cancer death. Bottom line: I’m left with an observation of the cancer pattern, but no good explanation or model.
Dr. Robert E. Buxbaum, May 1, 2014. Two other unsolved mysteries I’ve observed: the tornado drought of the last few years, and that dilute toxins and radiation may prevent cancer. To do science, you first observe, and then try to analyze.
Look at the pesticide roundup (glyphosate) map for the united states. It matches almost identically to your cancer map. The Yukon is still an outlier but that area might have a different explanation.
I agree with comment about agricultural run off. Pesticides, fertilizers, and waste probably go straight into the river and are known to cause cancer. Especially with the stupidly growing trend of round-up ready everything. There’s a reason it’s banned in other major countries…
I’m curious if there is any correlation in your map to the new link being noted in the news about Vitamin D deficiency and colorectal cancer (meaning maybe there is a broader link between Vitamin D – and where people are more exposed to the sun – and cancer overall?). Altitude, desert, coast? People wearing more sunscreen? Of course it wouldn’t be that simple, but wasn’t something that had been brought up, so thought I’d ask if that might be a factor worth pursuing.
Hello,
Would this explain higher cancer rates along rivers and less in mountains and deserts?
I’d like to share information I learned during my workplace’s outbreak of an underdiagnosed airborne infectious disease that can cause malignancies, precancerous conditions, rheumatological diseases, connective tissue diseases, heart disease, autoimmune symptoms, inflammation in any organ/tissue, seizures, migraines, mood swings, hallucinations, etc. and is often undiagnosed/misdiagnosed in immunocompetent people. 80-90+% of people in some areas have been infected, and it can lay dormant for up to 40 years in the lungs and/or adrenals.
My coworkers and I, all immunocompetent, got Disseminated Histoplasmosis in Dallas-Fort Worth from roosting bats, the most numerous non-human mammal in the U.S., that shed the fungus in their feces. The doctors said we couldn’t possibly have it, since we all had intact immune systems. The doctors were wrong. Healthy people can get it, too, with widely varying symptoms. And we did not develop immunity over time. We’d get better and then progressively worse, relapsing periodically and concurrently every year.
More than 100 outbreaks have occurred in the U.S. since 1938, and those are just the ones that were figured out, since people go to different doctors. One outbreak was over 100,000 victims in Indianapolis.
It’s known to cause hematological malignancies, and some doctors claim their leukemia patients go into remission when given antifungal. My friend in another state who died from lupus lived across the street from a bat colony. An acquaintance with alopecia universalis and whose mother had degenerative brain disorder has bat houses on their property.
There’s too much smoke for there not to be at least a little fire.
Researchers claim the subacute type is more common than believed. It’s known to at least “mimic” autoimmune diseases and cancer and known to give false-positives in PET scans. But no one diagnosed with an autoimmune disease or cancer is screened for it. In fact, at least one NIH paper states explicitly that all patients diagnosed with sarcoidosis be tested for it, but most, if not all, are not. Other doctors are claiming sarcoidosis IS disseminated histoplasmosis.
What if this infection, that made me and my coworkers so ill, isn’t rare in immunocompetent people? What if just the diagnosis is rare, since most doctors apparently ignore it? Especially since online documents erroneously state it’s not zoonotic.
Older documents state people who spend a lot of time in a building with roosting bats, in caves, working as landscapers, construction workers, pest control workers, etc. are known to get Disseminated Histoplasmosis, but the info appears to have been lost, for the most part. And now bat conservationists encourage people to leave bats in buildings/homes. What a terrible mistake they’ve made.
This pathogen parasitizes the reticuloendothelial system/invades macrophages, can infect and affect the lymphatic system and all tissues/organs, causes inflammation, granulomas, and idiopathic (unknown cause) diseases and conditions, including hematological malignancies, autoimmune symptoms, myelitis, myositis, vasculitis, panniculitis, dysplasia, hyperplasia, etc. It causes hypervascularization, calcifications, sclerosis, fibrosis, necrosis, eosinophilia, leukopenia, anemia, neutrophilia, pancytopenia, thrombocytopenia, hypoglycemia, cysts, abscesses, polyps, stenosis, perforations, GI problems, hepatitis, focal neurologic deficits, etc.
Many diseases it might cause are comorbid with other diseases it might cause, for example depression/anxiety/MS linked to Crohn’s.
The fungus is an Oxygenale and therefore consumes collagen. It’s known to cause connective tissue diseases (Myxomatous degeneration?), rheumatological conditions, seizures, and mental illness. Fungal hyphae carry an electrical charge and align under a current. It causes RNA/DNA damage. It’s known to cause delusions, wild mood swings (pseudobulbar affect?), and hallucinations. It’s most potent in female lactating bats, because the fungus likes sugar (lactose) and nitrogen (amino acids, protein, neurotransmitters?). What about female lactating humans…postpartum psychosis (and don’t some of these poor women also have trouble swallowing)? The bats give birth late spring/summer, and I noticed suicide rates spike in late spring/early summer. It’s known to cause retinal detachment, and retinal detachments are known to peak around June-July/in hot weather. A map of mental distress and some diseases appear to almost perfectly overlay a map of Histoplasmosis. Johns Hopkins linked autism to an immune response in the womb. Alzheimer’s was linked to hypoglycemia, which can be caused by chronic CNS histoplasmosis. The bats eat moths, which are attracted to blue and white city lights that simulate the moon the moths use to navigate. Bats feed up to 500 feet in the air and six miles away in any direction from their roost, but not when it’s raining or when the temperature is less than approximately 56° F. The fungus can grow in bird feces, but birds don’t carry it because their body temperature is too high, killing the fungus.
I believe the “side effects” of Haldol (leukopenia and MS symptoms) might not always be side effects but just more symptoms of Disseminated Histoplasmosis, since it causes leukopenia and MS symptoms. What about the unknown reason why beta receptor blockers cause tardive dyskinesia? The tinnitus, photophobia, psychosis “caused” by Cipro? Hypersexuality and leukemia “caused” by Abilify? Humira linked to lymphoma, leukemia and melanoma in children? Disseminated Histoplasmosis is known to cause enteropathy, so could some people thought to have nonsteroidal anti-inflammatory drug enteropathy have it and taking NSAIDs for the pain/inflammation it causes, and the NSAIDs aren’t the actual culprit?
From my experience, I learned that NO doctor, at least in DFW, will suspect subacute and/or progressive disseminated histoplasmosis in immunocompetent people. Some doctors, at least the ones I went to, will actually REFUSE to test for it, even when told someone and their coworkers have all the symptoms and spend a lot of time in a building with bats in the ceiling. Victims will be accused of hypochondriasis. In fact, the first doctor to diagnose me was a pulmonologist, and the only reason he examined me was to try to prove that I didn’t have it, when I really did. No doctor I went to realized bats carry the fungus. And NO doctor I went to in DFW, even infectious disease “experts,” understand the DISSEMINATED form, just the pulmonary form, and the only test that will be done by many doctors before they diagnose people as NOT having it is an X-ray, even though at least 40-70% of victims will have NO sign of it on a lung X-ray. It OFTEN gives false-negatives in lab tests (some people are correctly diagnosed only during an autopsy after obtaining negative test results) and cultures may not show growth until after 6-12 weeks of incubation (but some labs report results after 2 weeks).
One disease of unknown cause that could be caused by Disseminated Histoplasmosis: I suspect, based on my and my coworker’s symptoms (during our “rare” infectious disease outbreak) and my research, that interstitial cystitis and its comorbid conditions can be caused by disseminated histoplasmosis, which causes inflammation throughout the body, causes “autoimmune” symptoms, and is not as rare as believed. I read that “interstitial cystitis (IC) is a chronic inflammatory condition of the submucosal and muscular layers of the bladder, and the cause is currently unknown. Some people with IC have been diagnosed with other conditions such as irritable bowel syndrome (IBS), fibromyalgia, chronic fatigue syndrome, allergies, and Sjogren’s syndrome, which raises the possibility that interstitial cystitis may be caused by mechanisms that cause these other conditions. In addition, men with IC are frequently diagnosed as having chronic nonbacterial prostatitis, and there is an extensive overlap of symptoms and treatment between the two conditions, leading researchers to posit that the conditions may share the same etiology and pathology.” Sounds like Disseminated Histoplasmosis, doesn’t it?
My coworkers and I were always most ill around April/May/June, presumably since the Mexican Free-tail bats gave birth in Texas during May (and the fungus was most potent), and fall/Thanksgiving to December, for some unknown reason (maybe migrating bats from the north?). We had GI problems, liver problems, weird rashes (erythema nodosum, erythema multiforme, erythema annulare, etc.), plantar fasciitis, etc., and I had swollen lymph nodes, hives, lesions, abdominal aura, and started getting migraines and plantar fasciitis in the building, and I haven’t had them since I left. It gave me temporary fecal incontinence, seizures, dark blood from my intestines, tinnitus, nystagmus, benign paroxysmal positional vertigo, what felt like burning skin, various aches and pains (some felt like pin pricks and pinches), tingling, tremors, “explosions” like fireworks in my head while sleeping, temporary blindness, and chronic spontaneous “orgasms”/convulsions. Suddenly I was allergic to Comice pears (latex fruit allergy or oral allergy syndrome?). I had insomnia (presumably from the fungus acidifying the blood, releasing adrenaline) and parasomnias. I suddenly had symptoms of several inflammatory/autoimmune diseases, including Fibromyalgia, Sarcoidosis, ALS, MS, Sjogren’s syndrome, etc. that have disappeared since leaving the area and taking nothing but Itraconazole antifungal.
No one, including doctors (we all went to different ones), could figure out what was wrong with us, and I was being killed by my doctor, who mistakenly refused to believe I had it and gave me progressively higher and higher doses of Prednisone (at least 2 years after I already had Disseminated Histoplasmosis) after a positive ANA titer, until I miraculously remembered that a visiting man once told my elementary school class that bats CARRY histoplasmosis….so much of it that they evolved to deal with the photophobia and tinnitus it causes by hunting at night by echolocation. There’s a lot more. I wrote a book about my experience with Disseminated Histoplasmosis called “Batsh#t Crazy,” because bats shed the fungus in their feces and it causes delusions and hallucinations, I suspect by the sclerotia fungal mycelia can form emitting hallucinogens (like psilocybin and dimethyltryptamine) along with inflammation in the CNS. (Schizophrenics have 2X of a chemical associated with yeast, part of the fungal life cycle.)
Thank you for your time,
Susan McIntyre
P.S. Doesn’t this infection share all the same symptoms with Gulf War Syndrome?
The biggest factor is agricultural runoff. There are plenty of carcinogens, but nothing more prevalent and wide spread as those that make it into our farmed food. The Mississippi drains the vast majority of the agricultural base of the US, and most of the farming in that region is highly dependent on chemical that are known carcinogen. It isn’t so much rivers in general, but rather large rivers that drain vast tributaries of contaminated lands.
You can’t grow much food in the desert or the mountains, and water drains downhill, so the agricultural centers and the areas downstream are inevitably at higher risk.
There is no single cause, but this invariably plays a very important role. Similar health maps for obesity, life expectancy and income levels suggest you don’t want to live downstream from anything that nature didn’t make.
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And drinking water for cities away from rivers is usually supplied from aquifers below the surface of earth … much less likely to have hydrocarbons.
There are lots of way hydrocarbons can get in to rivers … spills, outboard motors, water run off etc.
Of course the water is treated by municipalities, but death blow is when they add chlorine to water that contains hydrocarbons already … even though they are in very dilute amounts.
Chlorinated hydrocarbons are notorious for being carcinogenic.
Many of the people on the city get drinking water (thru muncipality) from the rivers … rivers contain many small amounts of carcinogenic compounds … mostly hydrocarbons that combine with chlorine which is used in the purification of drinking water.
Some pretty obvious conclusions about heavy coal mining areas. Thanks.