Category Archives: Business

Package postage from China: 70¢ for 2 oz.

The minimum US postage rate to send a 1 oz to 8 oz package across the street is $8.30. This is the price for any size package going in “zone 1”. That is, to a nearby, instate address. It costs more to send a package to nearby states or across the country, zones 2,3,4,5,6,7, 8 You don’t get shipping updates or delivery confirmation unless you pay more. By comparison the US post office charges no more than $1.50 to Chinese companies to deliver packages of up to 4.4 lbs (2 kg) and they get shipping and delivery confirmation thrown in free. The high US rates are, in part, because the post office is losing money to subsidize postage from China.

On the internet folks are amazed at how cheap things are shipped from China (I copied this post from this Forbes article)

US producers can not compete on the sale of small items, in part, because we subsidize the shipping costs. Go to Amazon or e-Bay and you can buy from China packaged items shipped by air for a total price of $1 or so. That includes the price of the item, the shipping cost, and some profit for Amazon or eBay. A US supplier could not sell this cheap even if it were a box of air. The low shipping costs result from a poorly negotiated postage deal of 2011 between us (Obama’s negotiator) and the Chinese. Until 2021, we are committed to deliver a package of 50g or less, (2 oz) for 5 Chinese Yuan, or 70¢ at the current exchange rate of 14¢/NCY. Additional ounces are billed at 35¢ up to 4.4 lbs; use the following table of prices and apply the dollar to CNY conversion. We threw in tracking services and an e-mail confirmation for free, in part because China was poor, and we were rich. Also, the deal was pushed by e-Bay and Amazon, two big supporters of Obama’s presidency.

US suppliers cannot compete.

Adding insult to injury, Obama raised the de minimis amount for billing tariffs from the normal $100 to $800 making almost all purchases from China duty free. Obama made some complaints about unfair trade, and about the counterfeits and knockoffs but no major enforcement. In 2012 and 2014, the Obama administration signed similar postage deals with Korea, Hong Kong, and the EU. The Germans applauded as it allows them to ship goods to the US for far less than the cost of us shipping to Germany. The US post office loses money on this and makes up for it by charging us more for domestic mail.

The Washington Post praised Obama on these deals claiming that they benefitted US customer and promoted democracy. Of course, the Washington Post is owned by Amazon’s main stock holder, Jeff Bezos– someone who benefits very much by the deal. He is among the relatively few people and organizations that own the media outlets. The Post loses money on newspaper sales but benefits the owners by the propaganda value of the stories, a situation also found with Al Jazeera and the emir of Qatar.

Trump has informed China that these special rates will end when the treaty runs out in January 1, 2021. A per-package ship fee will be $3.00 for a one ounce package, with 11¢ per additional once. This is less than the domestic rate, but far higher than the current 35¢ for 1 oz. I’d probably have raised their postage even more, but this is an election year, and Biden may well reverse any deal Trump signs.

Robert Buxbaum, July 14, 2020. Though I’m appalled by this postage deal, I just bought a 50 lb kayak from China, $99.99 including shipping. The prices are too low to pass up.

Methuselah palm finds a mate after 2100 years

The Judean date palm was extinct until 15 years ago, remembered only through pictures, eg. on ancient coins, see below, and mentions in ancient books including the psalms of David. There were also some ancient seeds, 2100 years old, that had been found buried in a jar near the entry ramp of the fortress Masada. Sarah Sallon of Israel’s Natural Medicine Research Center became convinced that these dates had medicinal as well as historical value, and badgered the archeologists for seed samples and permission to try her luck reviving this extinct plant. The archeologists thought she was nuts but eventually she got permission to try her luck with some seeds that Prof Ehud Netzer, had stored in his desk.

Dr. Elaine Solowey, Dr. Elaine Solowey, Director of the Center for Sustainable Agriculture, and, the Methuselah tree. Note the distinctive leaves. The tree is not ten feet tall and ready to mate.

Against all odds, Dr. Sallon, in 2005, succeeded in germinating one of these ancient seeds, a feat thought to be botanically impossible. Named, Methuselah it was the oldest seed ever grown, attracting wide international attention. But it was a one-off, a male without a female plant.

Methuselah was, at that point, a historic artifact – an interesting tourist attraction at the center fro sustainable agriculture. There was no way to grow the famous Judaic dates, though without a female parent. But Dr. Sallon was undeterred, she found another archaeologist who had recovered a trove of date seeds from various sites in Qumran — the site where the Dead Sea scrolls had been discovered, plus from the Wadi Makukh and the Wadi Kelt. Some of these seeds were as old as the one that produced Methuselah.

Vespasian coin with Judaean palm and the legend “Iudaea Capta.” (Judea is captured). A Judean date palm is shown along with a mourning Jew and a triumphant Roman.

A group headed by Dr. Sallon, selected a total of 34 seeds for further study, choosing specimens that appeared to be visually to be intact, whole seeds, in good condition, and without holes. Chosen to study included more seeds from Masada (8 seeds), Qumran (18 seeds), Wadi Makukh (7 seeds), and Wadi Kelt (1 seed). The seeds were identified by code numbers, photographed, and measured for weight and length (with the exception of Masada seeds, which unfortunately were not measured). One date seed, from the Qumran excavations (HU 37 A11), was selected as a control and left unplanted.

The remaining 33 seeds were subjected to a preparatory process to increase the likelihood of germination): the seeds were soaked in water for 24 hours and in gibberellic acid (5.19 mM) (OrthoGrow, USA) for 6 hours to encourage embryonic growth. This was followed by Hormoril T8 solution (5 g/liter) (Asia-Riesel, Israel) for 6 hours to encourage rooting and KF-20 organic fertilizer (10 ml/liter) (VGI, Israel) for 12 hours. All solutions were maintained at 35°C.

Following the above procedure, one seed was found to be damaged and not planted. The others were separately potted in sterile potting soil, 1 cm below the surface, and placed in a locked quarantine site at the Arava Institute of Environmental Sciences in southern Israel.

The six young trees. the two females are at the bottom right.

Six of these germinated. Periodically they were treated with KF-20 (10 ml/liter) and iron chelate (10 g/liter). Irrigation used desalinated water, as the previous study indicated that using the region’s highly mineralized water produced “tip burn” (darkening and drying of leaves). The seeds that did not germinate were removed for further testing and the shells of the seeds that did sprout were tested to determine their sex,  Of the six, two were determined to be female and four male. The female plants have been named Judith and Hannah, two Biblical names associated with children. It will be many years before they can mate, but it’s a hopeful start. The four other plants are Adam, Jonah, Urial, and Boaz. Radio-carbon dating suggests that one of these female seeds is 2100 years old, like Methuselah, while the other is only 1900 years old. See article in AAAS.

If either of the female plants survives to maturity, and if they prove to be compatible, we may yet get to eat of the famous biblical fruit. When the Bible calls Israel is called the land of milk and honey, the honey is the date honey of this tree.  Will these dry bones yet rise and live? Perhaps so. Dr. Solloway seas the revival of this plant as a symbol of hope. I do too.

Robert E. Buxbaum, June 7, 2020, There is a bit of Frankenstein in any revival of the dead, but I’m ore comfortable bringing back ancient plants than bringing back the Wooly Mammoth, the passenger pigeon, or the T Rex.

When prostitution was legal in America, 1863-65.

Readers of this blog know that I am not a fan of very harsh punishments for crime, in particular for crimes that have no direct victim, e.g. drug possession and sales. Prostitution is another crime with no direct victim. One could argue that society as a whole is the victim, but my sense is that punishments should be minimal and targeted, e.g. to prevent involuntary human trafficking and disease. Our current laws, depicted here, are clearly not designed for this, but there was a brief period where prostitution laws did make more sense. During the civil war, civil war, prostitution was legal and regulated to prevent disease.

In 1862, Union forces captured the southern cities of Nashville and Memphis, Tenn. Major Gen. William Rosecrans set up headquarters in Nashville. Before the war, Nashville was home to 198 white prostitutes and nine  “mulatto,” operating in a two-block area known as “Smoky Row.” 

By the end of 1862,  Smokey row had grown and these numbers swelled to 1,500 “public women”. White southern women turned to prostitution out of poverty, largely. Their husbands were dead, or ill paid, and they were joined by recently freed slaves. Benton E. Dubbs, a Union private, reported a saying that “no man culd [sic] be a soldier unless he had gone through Smokey Row,” … “The street was about three-fourths of a mile long and every house or shanty on both sides was a house of ill fame. Women had no thought of dress or decency. They say Smokey Row killed more soldiers than the war.” 

By 1863, venerial disease was becoming a major problem. The Surgeon General would document 183,000 cases of venereal disease in the Union Army alone, “…the Pocks and the Clap. The cases of this complaint is numerous, especially among the officers.”  

Permit for Legal prostitution signed by Col George Spaulding.

At first General Rosecrans directed his assistant, Colonel Spaulding, to remove the women by sending them to other states, first by train, and then by boat commandeering the ship, Idaho for the purpose. The effect was horrible, not only was the ship turned back by every city, but the departure of these ladies just resulted in the appearance of a new cohort of sex-workers. By the time the Idaho had returned, Rosecrans had been relieved of command following embarrassing defeats at Chickamauga and Chattanooga . Col. Spaulding now tried a new technique to stop the plague of VD: legalized prostitution. It worked.

Women’s hospital during the war, Nashville.

For a $5/month fee a “public woman” could become a legal prostitute, or “Public Woman” so long as she submitted to monthly health inspections for a certificate of her soundness. If found infected, she was to report to a hospital dedicated to this treatment, was subject to imprisonment if she operated without the license and certificate. The effect was a major decline in sexually-transmitted disease, and an improvement (so it is claimed) in the quality of the services. The fees collected were sufficient to cover the cost of the operation and hospital, nearly.

At the end of the war, Col Spaulding and the union soldiers left Nashville, and prostitution returned to being illegal, if tolerated. One assumes that the VD rates went up as well.

George Spaulding, Congressman..

Colonel Spaulding and man. General Rosecrans are interesting characters beyond the above. Spaulding had entered the war as a private, and rose through the ranks to be a colonel. After the war, he became postmaster of Monroe Michigan, 1866 to 1870, Treasury agent, 1871 to 1875, Mayor of Monroe, 1876 to ?, President of the board of education, a lawyer in 1878, On the board of the Home for Girls 1885 to 1897, and congressman for the MI 2nd district (Republican) 1894 -1898. In his later years, he served as postmaster in Monroe, 1899 to 1907.

William Rosecrans was a Catholic, and an engineer-inventor graduate from West Point. In 1853, he designed St. Mary’s Roman Catholic Church, one of the largest US churches at the time, site of the wedding of John Kennedy and Jacqueline Bouvier. He designed and installed one of the first lock systems in Western Virginia. He and two partners built an early oil refinery. He patented a method of soap making and the first kerosene lamp to burn a round wick, and was one of the eleven incorporators of the Southern Pacific Railroad. He served as Ambassador to Mexico, 1868-69 and was congressman from California, 1st district (Democrat) 1880 – 1884. A success story, Rosecrans could not stand either Grant or Garfield, and fought against Grant getting a retirement package.

Robert Buxbaum, June 5, 2020. There are other ways to stop the spread of sexual diseases. During the AIDS epidemic, condoms were the preferred method, and during the current COVID crisis, face masks are being touted. My preference is iodine hand wash. All methods work if they can reduce the transmission rate, Ro below 1.

Biden’s touching problem.

Ex VP, Joe Biden has a long history of touching people in uncomfortable ways. He does it with men and women, and has a particular problem with children. As bad as it is to grab a sheriff on the leg, or Hillary Clinton when she clearly does not want to be grabbed, it’s quite a lot worse to fondle the hair and face of a child you are not related to (above). An expert reviewing the video of his many grabs, pats, and hair sniffs, came to conclude that Biden behaves like a predator.

Biden grabs a sheriff in a ways that most find inappropriate. He says’s its just his way to make a connection. Others say it’s ‘his power move.’

Adding to Biden’s touching problems, Tara Reade, one of Biden’s staffers has come forward to say that Biden not only made her feel uncomfortable, but pinned her to a wall at the capital building, penetrated her with his hand, and asked for sex. When a panel of experts went over her testimony and Biden’s denial, they came away believing Tara, and not believing Biden. Here is a video with them discussing the various tells that cause them to doubt Biden. Here is another video with the same individuals discussing Reade’s accusation.

Biden applies his power move on Secretary of State Clinton.

What’s to be done? There are still may in the Democratic party who would like to see Biden drop out in favor of someone less tainted, like Bernie. Others, like Illan Omar have concluded that despite Biden being a predator, she supports him as providing the best chance to defeat Donald Trump.

Robert Buxbaum, June 4, 2020

Brazilian scientists speak out for hydroxychloroquine

Brazil has decided to go its own route in response to the Corona virus pandemic. They’re using minimal social distancing with a heavy reliance on hydroxychloroquine (HCQ), a cheap drug that they claim is effective (as has our president). Brazil has been widely criticized for this, despite so far having lower death rate per million than the US, Canada, or most of Europe. In an open letter, copied in part below, 25 Brazilian scientists speak out against the politicalization of science, and in favor of their approach to COVID-19. The full letter (here). The whole letter is very worth reading, IMHO, but especially worthwhile is their section on hydroxychloroquine (HCQ), copied below.

….. Numerous countries such as the USA, Spain, France, Italy, India, Israel, Russia, Costa Rica and Senegal use the drug (HCQ) to fight covid-19, whereas other countries refrain from using HCQ as one of the strategies to contain the pandemic, betting on other controversial tactics.

Who then speaks here in the name of “science”? Which group has a monopoly on reason and its exclusive authorization to be the spokesperson of “science”? Where is such authorization found?One can choose an opinion, and base his strategy on it, this is fine, but no one should commit the sacrilege of protecting his decision risking to tarnish with it the “sacred mantle of science”.

Outraged, every day I hear mayors and governors saying at the top of their lungs that they “have followed science”. Presidents of councils and some of their advisers, and of academies and deans in their offices write letters on behalf of their entire community, as if they reflect everyone’s consensual position. Nothing could be more false.Have they followed science? Not at all! They have followed the science wing which they like, and the scientists who they chose to place around them. They ignore the other wing of science, since there are also hundreds of scientists and articles that oppose their positions and measures.

Worse, scientists are not angels. Scientists are people, and people have likes and dislikes, passions and political party preferences. Or wouldn’t they? There are many scientists, therefore, who do good without looking at whom, I know and admire many of them. But there are also pseudoscientists who use science to defend their opinion, their own pocket, or their passion. Scientists have worked and still work hard and detached to contribute to the good of humanity, many of whom are now in their laboratories, risking their lives to develop new methods of detecting coronavirus, drugs and vaccines, when they could stay “safe at home”. But, to illustrate my point, I know scientists who have published articles, some even in major journals such as “Science” or “Nature”, with data they have manufactured “during the night”; others who have removed points from their curves, or used other similar strategies. Many scientists were at Hitler’s side, weren’t they? Did they act in the name of “science”? Others have developed atom bombs. Others still develop chemical and biological weapons and illicit drugs, by design.

The Manaus’ study with chloroquine (CQ) performed here in Brazil and published in the Journal of the American Medical Association (JAMA) [1], is emblematic to this discussion of “science”. Scientists there used, the manuscript reveals, lethal doses in debilitated patients, many in severe conditions and with comorbidities. The profiles of the groups do not seem to have been “randomized”, since a clear “preference” in the HIGH DOSE group for risk factors is noted. Chloroquine, which is more toxic than HCQ, was used, and it seems that they even made “childish mistakes” in simple stoichiometric calculations, doubling the dosage with the error. I’m incapable of judging intentions, but justice will do it. The former Brazilian Health Minister Luiz Henrique Mandetta quoted this study, supported it, and based on it, categorically stated: “I do not approve HCQ because I am based on ‘science, science, science’!”.

Another study published by Chinese researchers in the British Medical Journal (BMJ) and which is still persistently used against HCQ was also at least revolting [2]. In it, the authors declared: “we administer 1,200 mg for 3 days, followed by 800 mg for 12 to 21 days, in patients with moderate to severe symptoms”. In other words, they gave a huge dosage of the drug that could reach the absurdity of 20 grams in the end, and it given was too late to patients (HCQ should be administered in the first symptoms or even earlier). And even worse, overdosing on HCQ or any other drug for severe cases is poisonous. What do you think, was it good science? The recommended dosage in Brazil, since May 20th, 2020, by the new Ministry of Health, for mild symptoms is 2 times 400 mg in the first day (every 12 hours) and 400 mg for 5 days for a total of 2.8 grams.

In other published studies, also in these internationally renowned journals such as The New England Journal of Medicine, JAMA and BMJ [3-5], once again, “problems” are clearly noted, since or the patients were randomized in irregular ways, placing older, more susceptible or most severe and hypoxemic patients in the higher (lethal) dose groups, or more men (almost 3 times more deadly by covid than women), or more black people (in the USA, black people have displayed higher mortality) and more smokers, and where most of the deaths occurred in the first days of the studies (signs that were deaths of critically ill patients, who at this stage would be more “intoxicated” than “treated” with HCQ), or they administered HCQ isolated, when it is known that it is necessary to associate HCQ at least with azithromycin. One of these studies [5] administered HCQ only on the sixteenth day of symptoms (for really early treatment, HCQ administration should be started up to fifth day), in other words, at the end of the disease, when the drug can do little good or nothing to the patient.

These studies indicate that some scientists either forgot how “science” is done or that there is a huge effort to disprove, whatever it takes, that HCQ works. How can someone or even Councils and Academies of Medicine cite such studies as the “science” of their decisions? How can that be?

On the contrary, the study published – and today with more than 3 thousand patients tested – and carried out by Dr. Didier Raoult in France [6], using the correct dosage and at the right time, with a very low mortality rate (0.4%), and the Prevent Senior’s clinical experience in Brazil – also quite encouraging – are disqualified with very “futile” arguments such as: “Didier Raoult is a controversial and unworthy researcher”, “At Prevent Senior Clinic they were not sure of the diagnosis” (but none of the hospitalized patients with clear COVID symptoms died), “Placebo effect” (what a supernatural power of inducing our mind that reduces mortality from 40% to zero, I want this placebo!), “Study performed by a health plan company” (I do not doubt that this people indeed want to save lives, because the patients were their customers who pay their bills), and similar ephemeral arguments.

The Brazilian scents who signed the letter. Read the whole letter here.

I admire the spunk of these fellows going agains the doctors, WHO. Beyond being a critique of bad research on a particular drug, it is a defense of science. Science is a discussion, a striving for truth. It is not supposed to demand blind allegiance to a few politically appointed experts. They’ve convinced me that the tests sponsored by the world health organization seem designed to show failure, and reminded me that there is rarely a one-size-fits-all for problems and all times.

I also find striking the highly critical response of my local newspapers and TV reporters. While they both like to highlight efforts by South America as they try entering the first world, with help from Bill gates and leftist politicians, they have been uniformly condemned Brazil for its non-left approach and now for use of HCQ. They want Sous Americans to think, but only if their conclusions are no different from those of their favorite, liberal thinkers.

Robert Buxbaum, May 28, 2020. Check out my notes on how to do science right. And by the way, you might want to use iodine hand wash to minimize your chance of getting or spreading COVID and other diseases.

Iodine is far better than soap or alcohol sanitizer.

I’m a fan of iodine both as a hand sanitizer, and as a sanitizer for surfaces. II’ve made gallons of the stuff for my own use and to give away. Perhaps I’ll come to sell it too. Unlike soap washing or alcohol sanitizer, iodine stays on your hands for hours after you use it. Alcohol evaporates in a few seconds, and soap washes off. The result is that iodine retains killing power after you use it. The iodine that I make and use is 0.1%, a concentration that is non-toxic to humans but very toxic to viruses. Here is an article about the effectiveness of iodine against viruses and bacteria Iodine works both on external surfaces, and internally, e.g. when used as a mouthwash. Iodine kills germs in all environments, and has been used for this purpose for a century.

With normal soap or sanitizer it’s almost impossible to keep from reinfecting your hands almost as soon as you wash. I’ve embedded a video showing why that is. It should play below, but here’s the link to the video on youtube, just in case it does not.

The problem with washing your hands after you receive an item, like food, is that you’re likely to infect the sink faucet and the door knob, and the place where you set the food. Even after you wash, you’re likely to re-infect yourself almost immediately and then infect the towel. Because iodine lasts on your hands for hours, killing germs, you have a good chance of not infecting yourself. If you live locally, come by for a free bottle of sanitizer.

For those who’d like more clinical data to back up the effectiveness of iodine, here’s a link to a study, I also made a video on the chemistry of iodine relevant to why it kills germs. You might find it interesting. It appears below, but if it does not play right, Here’s a link.

The video shows two possible virus fighting interactions, including my own version of the clock reaction. The first of these is the iodine starch interaction, where iodine bonds forms an I<sub>3</sub><sup>-</sup> complex, I then show that vitamin C unbinds the iodine, somewhat, by reducing the iodine to iodide, I<sup>-</sup>. I then add hydrogen peroxide to deoxidize the iodine, remove an electron. The interaction of vitamin C and hydrogen peroxide creates my version of the clock reaction. Fun stuff.

The actual virus fighting mechanism of iodine is not known, though the data we have suggests the mechanism is a binding with the fatty starches of the viral shell, the oleo-polysaccharides. Backing this mechanism is the observation that the shape of the virus does not change when attacked by iodine, and that the iodine is somewhat removable, as in the video. It is also possible that iodine works by direct oxidation, as does hydrogen peroxide or chlorine. Finally, I’ve seen a paper showing that internal iodine, more properly called iodide works too. My best guess about how that would work is that the iodide is oxidized to iodine once it is in the body.

There is one more item that is called iodine, that one might confuse with the “metallic” iodine solutions that I made, or that are sold as a tincture. These are the iodine compounds used for CAT-scan contrast. These are not iodine itself, but complex try-iodo-benzine compounds. Perhaps the simplest of these is diatrizoate. Many people are allergic to this, particularly those who are allergic to sea food. If you are allergic to this dye, that does not mean that you will be allergic to a simple iodine solution as made below.

The solution I made is essentially 0.1% iodine in water, a concentration that has been shown to be particularly effective. I add potassium iodide, plus isopropyl alcohol, 1%, 1% glycerine and 0.5% mild soap. The glycerine and soap are there to maintain the pH and to make the mix easier on your hands when it dries. I apply 5-10 ml to my hands and let the liquid dry in place.

Robert Buxbaum April 27, 2020; I’m running for water commissioner again. Wishing you a safe and happy lockdown,

Virus and cancer treatment by your immune system

There are two standard treatments for a disease. One is through a chemical, pill or shot, often using a patented antibiotic or antiviral molecule, sometimes a radioactive chemical or anti-inflammatory. There have been quite a lot of success with these molecules especially against bacterial disease. E.g. penicillin, a molecule found in cheese, was quite effective against infection, syphilis, and even the viral disease, rabies. Still, in surprisingly many cases, a molecule that you’d expect should cure a disease does not. For this reason, recent research has looked into the other approach to a cure — use your own immune system.

In the most basic version of this approach, that of Paracelcius, is to give the patient nothing beyond sunshine, a clean dressing, and good food. In surprisingly many cases, this is enough to allow the patient’s own immune system will fight the disease successfully. Currently, this seems like our best option to fight COVID-19, the new Wuhan coronavirus.; antivirals seem to have no particular effect on COVID-19, as with rabies, but patients do get better on their own with time, and there is some indication that sunlight helps too, at least in fighting the disease spread, and perhaps in effecting a cure.

Your immune system is remarkably flexible. When it is up to the task, as in the video below white blood cells multiply enormously around the invader and attack. The white cells do not harm your body cells nor those of friendly bacteria, but rally to kill nearly any invader, even one the cells have never seen before. There is a minimum of side effects (fever, tiredness) but these go away after the invader is gone. The immune system then keeps the memory of the invader alive via “Memory T cells” so that it can attack more quickly if the same invader is seen again. This is what we call immunity, and it’s a type of protection that you generally don’t get from pills.

View post on imgur.com

Unfortunately, not every disease is fought well by the immune system alone. Measles, for example, or smallpox. For several of these diseases we’ve found we can activate the patient’s immune system with a vaccination, even after the patient contacts the disease. An injection of a weaker form of the disease seems to help kick-start the patients own immune system. Vaccination tends to have bad side-effects, but for many diseases, e.g. measles, the bad is outweighed by the good. Interestingly we’ve begun to use this approach on some cancers, too, and it seems to work. Immune therapy, it’s called.

Immune therapy is not generally the first line approach to cancer, but it might be the best for slow cancers, like prostate. Generally, in the fight against cancer, the preferred method is to removes as much of cancer cells as possible, and treat any missed cells using a mix of radiation and chemicals. This works but there are a lot of side-effects. Immune therapy is sort of similar, in a way. Instead of irradiating the bad cells inside the body, one takes the cancer cells outside of the body (or the virus molecules) and uses radiation and chemicals to knock off bits. These bits, a weakened form of the cancer or of the virus, are then cultured and re-injected into the body. Sometimes it works, sometimes not. For melanoma, skin cancer, immune therapy is found to works about 1/4 of the time. Why not more? It seems that sometimes the immune system gets “exhausted” fighting a foe that’s to much for it. And sometimes the activated immune system starts attacking the host body. This is an auto-immune response.

Dr. Robert E. Buxbaum, February 21, 2020

COVID-19 is worse than SARS, especially for China.

The corona virus, COVID-19 is already a lot worse than SARS, and it’s likely to get even worse. As of today, there are 78,993 known cases and 2,444 deaths. By comparison, from the first appearance of SARS about December 1 2002, there have been a total of 8439 cases and 813 deaths. It seems the first COVID-19 patient was also about December 1, but the COVID-19 infection moved much faster. Both are viral infections, but it seems the COVID virus is infectious for more days, including days when the patient is asymptomatic. Quarantine is being used to stop COVID-19; it was successful with SARS. As shown below, by July 2003 SARS had stopped, essentially. I don’t think COVID-19 will stop so easily.

The process of SARS, worldwide; a dramatic rise and it’s over by July 2003. Source: Int J Health Geogr. 2004; 3: 2. Published online 2004 Jan 28. doi: 10.1186/1476-072X-3-2.

We see that COVID-19 started in November, like SARS, but we already have 10 times more cases than the SARS total, and 150 times more than we had at this time during the SARS epidemic. If the disease stops in July, as with SARS, we should expect to see about a total of 150 times the current number of cases: about 12 million cases by July 2020. Assuming a death rate of 2.5%, that suggests 1/4 million dead. This is a best case scenario, and it’s not good. It’s about as bad as the Hong Kong flu pandemic of 1968-69, a pandemic that killed 60,000 approximately in the US, and which remains with us, somewhat today. By the summer of 69, the spreading rate R° (R-naught) fell below 1 for and the disease began to die out, a process I discussed previously regarding measles and the atom bomb, but the disease re-emerged, less infectious the next winter and the next. A good quarantine is essential to make this best option happen, but I don’t believe the Chinese have a good-enough quarantine.

Several things suggest that the Chinese will not be able to stop this disease, and thus that the spread of COVID-19 will be worse than that of the HK flu and much worse than SARS. For one, both those disease centered in Hong Kong, a free, modern country, with resources to spend, and a willingness to trust its citizens. In fighting SARS, HK passed out germ masks — as many as anyone needed, and posted maps of infection showing places where you can go safely and where you should only go with caution. China is a closed, autocratic country, and it has not treated quarantine this way. Little information is available, and there are not enough masks. The few good masks in China go to the police. Health workers are dying. China has rounded up anyone who talks about the disease, or who they think may have the disease. These infected people are locked up with the uninfected in giant dorms, see below. In rooms like this, most of the uninfected will become infected. And, since the disease is deadly, many people try to hide their exposure to avoid being rounded up. In over 80% of COVID cases the symptoms are mild, and somewhat over 1% are asymptomatic, so a lot of people will be able to hide. The more people do this, the poorer the chance that the quarantine will work. Given this, I believe that over 10% of Hubei province is already infected, some 1.5 million people, not the 79,000 that China reports.

Wuhan quarantine “living room”. It’s guaranteed to spread the disease as much as it protects the neighbors.

Also making me think that quarantine will not work as well here as with SARS, there is a big difference in R°, the transmission rate. SARS infected some 2000 people over the first 120 days, Dec. 1 to April 1. Assuming a typical infection time of 15 days, that’s 8 cycles. We calculate R° for this stage as the 8th root of 2000, 8√2000 = 2.58. This is, more or less the number in the literature, and it is not that far above 1. To be successful, the SARS quarantine had to reduce the person’s contacts by a factor of 3. With COVID-19, it’s clear that the transmission rate is higher. Assuming the first case was December 1, we see that there were 73,437 cases in only 80. R° is calculated as the 5 1/3 root of 73,437. Based on this, R° = 8.17. It will take a far higher level of quarantine to decrease R° below 1. The only good news here is that COVID-19 appears to be less deadly than SARS. Based on Chinese numbers the death rate appears to be about 2000/73,437, or about 3%, varying with age (see table), but these numbers are overly high. I believe there are a lot more cases. Meanwhile the death rate for SARS was over 9%. For most people infected with COVID-19, the symptoms are mild, like a cold; for another 18% it’s like the flu. A better estimate for the death rate of COVID-19 is 0.5-1%, less deadly than the Spanish flu of 1918. The death rate on the Diamond Princess was 3/600 = 0.5%, with 24% infected.

The elderly are particularly vulnerable. It’s not clear why.

Backing up my value of R°, consider the case of the first Briton to contact the disease. As reported by CNN, he got it at conference in Singapore in late January. He left the conference, asymptomatic on January 24, and spent the next 4 days at a French ski resort where he infected one person, a child. On January 28, he flew to England where he infected 8 more before checking himself into a hospital with mild symptoms. That’s nine people infected over 3 weeks. We can expect that schools, factories, and prisons will be even more hospitable to transmission since everyone sits together and eats together. As a worst case extrapolation, assume that 20% of the world population gets this disease. That’s 1.5 billion people including 70 million Americans. A 1% death rate suggests we’ll see 700,000 US deaths, and 15 million world-wide this year. That’s almost as bad as the Spanish flu of 1918. I don’t think things will be that bad, but it might be. The again, it could be worse.

If COVID-19 follows the 1918 flu model, the disease will go into semi-remission in the summer, and will re-emerge in the fall to kill another few hundred thousand Americans in the next fall and winter, and the next after that. Woodrow Wilson got the Spanish Flu in the fall of 1918, after it had passed through much of the US, and it nearly killed him. COVID-19 could continue to rampage every year until a sufficient fraction of the population is immune or a vaccine is developed. In this scenario, quarantine will have no long-term effect. My sense is that quarantine and vaccine will work enough in the US to reduce the effect of COVID-19 to that of the Hong Kong flu (1968), so that the death rate will be only 0.1 – 0.2%. In this scenario, the one I think most likely, the US will experience some 100,000 deaths, that is 0.15% of 20% of the population, mostly among the elderly. Without good quarantine or vaccines, China will lose at least 1% of 20% = about 3 million people. In terms of economics, I expect a slowdown in the US and a major problem in China, North Korea, and related closed societies.

Robert Buxbaum, February 18, 2020. (Updated, Feb. 23, I raised the US death totals, and lowered the totals for China).

Italian Engineering and the Kennedy assassination.

There are several unbelievable assertions surrounding the Kennedy assassination, leading many to conclude that Oswald could not have killed Kennedy alone. I believe that many of these can be answered once you realize that Oswald used an Italian gun, and not a US gun. Italian engineering differs from our in several respects that derive from the aesthetic traditions of the countries. It’s not that our engineers are better or worse, but our engineers have a different idea of what good engineering is and thus we produce designs that, to an Italian engineer, are big, fat, slow, and ugly. In our eyes Italian designs are light, fast, pretty, low-power, and unreliable. In the movie, Ford vs Ferrari, the American designer, Shelby says that, “If races were beauty contests, the Ferrari would win.” It’s an American, can-do, attitude that rings hollow to an Italian engineer. 

Three outstanding questions regarding the Kennedy assassination include: How did Oswald fire three bullets, reasonably accurately in 5 to 8 seconds. How did he miss the limousine completely on the first, closest shot, then hit Kennedy twice on the next two, after previously missing on a close shot at retired general, Edwin Walker. And how could the second shot have gone through Kennedy’s neck, then through his wrist, and through Connolly twice, emerging nearly pristine. I will try to answer by describing something of the uniquenesses of the gun and bullets, and of Italian engineering, in general. 

Oswald cartridge.

The rifle Oswald used was a Modello 91/38, Carcano (1938 model of a design originally used in 1891) with an extra-long, 20.9″ barrel, bought for only $19.95 including a 4x sight. That’s $12.50 for the gun, the equivalent of $100 in 2020). The gun may have been cheep, but it was a fine Italian weapon: it was small, fast, pretty, manual, and unreliable. The small size allowed Oswald to get the gun into the book depository without arousing suspicion. He claimed his package held curtain rods, and the small, narrow shape of the gun made the claim believable.

The first question, the fast shooting, is answered in part by the fact that loading the 91/38 Carcano rifle takes practice. Three American marksmen who tried to duplicate the shots for the Warren commission didn’t succeed, but they didn’t have the practice with this type of gun that Oswald had. The Carcano rifle used a bolt and clip loading system that had gone out of style in the US before WWI. To put in a new shell, you manually unlock and pull back the bolt. The old casing then flies out, and the spring–clip loads a new shell. You then have to slam the bolt forward and lock it before you can fire again. For someone practiced, loading this way is faster than with a semi-automatic. To someone without practice it is impossibly slow, like driving a stick shift car for the first time. Even with practice, Americans avoid stick shift cars, but Italians prefer them. Some time after the Warren report came out, Howard Donahue, an American with experience on this type of rifle, was able to hit three moving targets at the distance in 4.8 seconds. That’s less than the shortest estimate of the time it took Oswald to hit twice. Penn of Penn and Teller recreates this on TV, and shows here that Kennedy’s head would indeed have moved backward.

Oswald’s magic bullet, shot two.

That Oswald was so accurate is explained, to great extent by the way the sight was mounted and by the unusual bullets. The model 38 Carcano that Oswald bought fired light, hollow, 6.5×52mm cartridges. This is a 6.5 mm diameter bullet, with a 52 mm long casing. The cartridge was adopted by the Italians in 1940, and dropped by 1941. These bullets are uncommonly bullet is unusually long and narrow (6.5 mm = .26 caliber), round-nosed and hollow from the back to nearly the front. In theory a cartridge like this gives for greater alignment with the barrel., and provides a degree of rocket power acceleration after it leaves the muzzle. Bullets like this were developed in the US, then dropped by the late 1800s. The Italians dropped this bullet for a 7.5 mm diameter version in 1941. The 6.5 mm version can go through two or three people without too much damage, and they can behave erratically. The small diameter and fast speed likely explains how Oswald’s second shot went through Kennedy and Connolly twice without dong much. An American bullet would have done a lot more damage.

Because of the light weight and the extra powder, the 6.5 mm hollow bullet travels uncommonly fast, about 700 m/s at the muzzle with some acceleration afterwards, ideally. Extra powder packs into the hollow part by the force of firing, providing, in theory, low recoil, rocket power. Unfortunately these bullets are structurally weak. They can break apart or bend and going off-direction. By comparison the main US rifle of WWII, the M1, was semi-automatic, with bullets that are shorter, heavier, and slower, going about 585 m/s. Some of our bullets had steel cores too to provide a better combination of penetration and “stopping power”. Only Oswald second shot stayed pristine. It could be that his third shot — the one that made Kennedy’s head explode — flattened or bent in flight.

Oswald fragment of third bullet. It’s hollow and seems to have come apart in a way a US bullet would not.

The extra speed of Oswald’s bullets and the alignment of his gun would have given Oswald a great advantage in accuracy. At 100 yards (91 m), test shots with the rifle landed 2 12 to 5 inches high, within a 3-to-5-inch circle. Good accuracy with a sight that was set to high for close shot accuracy. The funky sight, in my opinion , explains how Oswald managed to miss Walker, but explains how he hit Kennedy accurately especially on the last, longest shot, 81 m to Kennedy’s head

Given the unusually speed of the bullets (I will assume 750 m/s) Oswald’s third shot would have taken 0.108 s to reach the target. If the sight were aligned string and if Kennedy were not moving, the bullet would have been expected to fall 2.24″ low at this range, but given the sight alignment we’d expect him to shoot 3-6″ high on a stationary target, and dead on, on the president in his moving vehicle. Kennedy was moving at 5 m/sand Oswald had a 17° downward shot. The result was a dead on hit to the moving president assuming Oswald didn’t “lead the shot”. The peculiarities of the gun and bullets made Oswald more accurate here than he’d been in the army, while causing him to miss Walker completely at close range.

comparison of the actual, second shot, “magic bullet,” left, with four test-shot bullets. Note that one of the test bullets collapsed, two bent, and one exploded. This is not a reliable bullet design.

We now get to the missed, first shot: How did he miss the car completely firing at the closest range. The answer, might have to do with deformation of the bullets. A hollow base bullet can explode, or got dented and fly off to the side. More prosaically, it could be that he hit a tree branch or a light pole. The Warren commission blamed a tree that was in the way, and there was also a light pole that was never examined. For all we know the bullet is in a branch today, or deflected. US bullets would have a greater chance to barrel on through to at least hit the car. This is an aspect of Italian engineering — when things are light, fast, and flexible, unusual things happen that do not expect to happen with slow, ugly, US products. It’s a price of excellence, Italian style.

Another question appears: Why wasn’t Oswald stopped when the FBI knew he’d threatened Kennedy, and was suspected of shooting at Walker. The simple answer, I think, is that the FBI was slow, and plodding. Beyond this, neither the FBI nor the CIA seem to have worried much about Kennedy’s safety. Even if Kennedy had used the bubble top, Oswald would likely have killed him. Kennedy didn’t care much for the FBI and didn’t trust Texas. Kennedy had a long-running spat with the FBI involving his involvement with organized crime, and perhaps running back to the days when Kennedy’s father was a bootlegger. His relation with the CIA was similar.

The Mateba, Italian semi-automatic revolver, $3000, available only in 357 Magnum and 44 magnum.

I should mention that the engineering styles and attitudes of a country far outlast the particular engineer.We still make big, fat, slow, ugly cars — that are durable and reasonably priced. Germans still overbuild, and Italian cars and guns are as they ever were: beautiful, fast, expensive, and unreliable. The fastest production car is Italian, a Bugatti with a top speed of 245 mph; the fastest rollercoaster is at Ferrari gardens, 149 mph, and in terms of guns, let me suggest you look at the Mateba, left, a $3000 beautiful super fast semi-automatic revolver (really), produced in Italy, and available in 357 magnum and .44 magnum only . It’s a magnificent piece of Italian engineering beautiful, accurate, powerful, and my guess is it’s unreliable as all get out. Our, US pistols typically cost 1/5 to 1/10 as much. A country’s cars, planes, and guns represent the country’s aesthetics. The aesthetics of a county changes only slowly, and I think the world is better off because of it

Robert Buxbaum, February 14, 2020. One of my favorite courses in engineering school, Cooper Union, was in Engineering Aesthetics and design.

Affirmative action for Elizabeth Warren, 1/1000 Indian

The following is Elizabeth Warren’s law registration for the state of Texas, 1986 claiming she is an American Indian. There was very little evidence for it and an genetic test showed she was somewhere between 1/256 and 1/1000 Indian. My son was determined to have 1/1000 Indian blood in a similar test, and we have no Indian ancestors at all, as best as I can tell. Still, as an Indian Ms. Warren is entitled to affirmative action; she’s to get preferential hiring financial, and educational treatment over someone more qualified, but without Indian blood. Affirmative action was institute as a way to redress the suffering of Indians and other minorities, but it is not clear that is serves this purpose when someone with so little, or no blood can take the advantage. There is no requirement of proof that you are at all Indian by blood, and even if you are 1/1000 Indian, what about the other 999/1000? Why don’t they count to give yo lower standing than someone who is 1/10 Indian, say. How indian should you have to be to get benefits.

Related to the question of how much Indian blood you should have to have to get benefits is the question of making other folks suffer to provide this benefit. Many of the people who suffer because of affirmative action are dependents of immigrant minorities, Jews, Italians, and Chinese, and these folks have not had it that well. The Italians were discriminated against in hiring, as mandated by the city council, see announcement below, and Chinese immigrants had very limited migration and work rights, as specified under The Chinese Exclusion Act of 1882. This act was not repealed until 1943 as part of our war against Japan.

In the late 1800s anti Italian discrimination was common. In part this was the Tammany Hall Irish doing their best to keep out an upstart immigrant group. Should Italians have affirmative action preferences?

At maximum Ms. Warren is less than 1% indians and thus over 99% Texan. This is to suggest that the majority of her bloodline is descent is from those who displaced the Indians, but her preferential hiring was likely in preference to other minorities who suffered too, and who likely have a purer bloodline to that suffering and exclusion than Ms Warren has. Is this what we want from affirmative action? The form we’ve got benefits, for the most part, only the most crooked, connected members of society. People like Ms Warren. I think this has to change.

Robert Buxbaum, January 23, 2020